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About this product
- PublisherSpringer-Verlag New York Inc.
- Date of Publication29/11/2010
- GenreMedical Nursing & Ancillary Services
- Series TitleMicrosystems
- Series Part/Volume Number16
- Place of PublicationNew York, NY
- Country of PublicationUnited States
- ImprintSpringer-Verlag New York Inc.
- Content Notebiography
- Weight629 g
- Width160 mm
- Height240 mm
- Spine21 mm
- Edited byGerald A. Urban
- Edition Statement1st ed. Softcover of orig. ed. 2006
- Table Of ContentsPreface EARLY BIOMEMS, MULTI-SENSOR NEUROPROBES 1. Introduction. 2. Evolution of micro-sensor array designs for medical research. 2.1 Electrical signal monitoring. 2.2 Sensor Design Evolution: from 2D to 3D. 2.3 Chamber-Type Electrochemical Oxygen Sensors. 3. Other Applications - the first micro-fluidic device. 4. Conclusion. 5. References. MULTI-PARAMETER BIOMEMS FOR CLINICAL MONITORING 1. Introduction. 2. Biosensors. 2.1 Principle of Biosensors. 2.2 Amperometric Biosensors. 2.3 Aspects of miniaturization and integration 3. Clinical Monitoring. 3.1 Multi-analyte measurement. 3.2 Microdialysis. 3.3 BioMEMS for clinical monotoring. 3.4 Multi-parameter monitoring. 3.5 Applications. 3.5.1 Monitoring of glucose and lactate with a micro-dialysis probe. 3.5.2 Ammonia monitoring. 4. Conclusions and outlook. 5. References. NEURAL IMPLANTS IN CLINICAL PRACTICE Interfacing neurons for neuro-modulation, limb control, and to restore vision - Part I 1. Introduction to Neural Implants. 2. Anatomical and Biophysical Fundamentals. 2.1 Peripheral Nerve Anatomy. 2.2 Mechanisms of Peripheral Nerve Damage. 2.3 Excitability of Nerves. 2.4 Electrical Modeling of the Nerve Membrane. 2.5 Propagation of Action Potentials. 2.6 Extra-cellular Stimulation of Nerve Fibres. 2.7 Selective Activation of Nerve Fibres. 3. Clinical Implants. 3.1 Electrodes - The Key Component in Neural Prostheses. 3.2 Cardiac Pacemakers. 3.3 Implantable Defibrillators. 3.4 Cochlea Implants. 3.5 Phrenic Pacemakers. 3.6 Grasp Neuroprostheses. 3.7 Neuroprostheses for gait and posture. 3.8 Spinal Root Stimulator. 3.9 Drop Foot Stimulator. 3.10 Neuro-modulation. 3.11 Deep Brain Stimulation. 3.12 Vagal Nerve Stimulation. 4. References. BIOMEDICAL MICRODEVICES FOR NEURAL IMPLANTS Interfacing neurons for neuromodulation, limb control, and to restore vision - Part II 1. The Challenge of Microimplants. 2. Vision Prostheses. 2.1 Cortical Vision Prostheses. 2.2 Optic Nerve Vision Prosthesis. 2.3 Retinal Implants. 2.3.1 Subretinal Vision Prostheses. 2.3.2 Epiretinal Vision Prostheses. 2.4 Conclusions on Vision Prostheses. 3. Periphereral Nerve interfaces. 3.1 Non-Invasive Nerve Interfaces. 3.2 Semi -Invasive Interfaces. 3.3 Invasive Interfaces. 3.3.1 Intrafascicular Electrodes. 3.3.2 Needle-Like Electrodes. 3.3.3 Regenerative type electrode. 3.4 Biohybrid Approaches. 4. Future Applications. 4.1 Interfacing the Brain. 4.2 Spinal Cord Implants. 4.3 Multi-modal Neural Implants. 5. Concluding Remarks. 6. Neural Implants: Boon or Bane? 7. References. MICRO-FLUIDIC PLATFORMS 1. Introduction. 2. What is a micro-fluidic platform. 3. Examples of micro-fluidic platforms. 3.1 PDMS based Micro-fluidics for Large Scale Integration ( Fluidigm platform ). 3.2 Micro-fluidics on a Rotating Disk ( Lab-on-a-Disk ). 3.3 Droplet based micro-fluidics (DBM). 3.3.1 DBM based on electro-wetting. 3.3.2 DBM based on surface acoustic waves. 3.3.3 DBM based on two phase liquid flow. 3.4 Non-contact liquid dispensing. 3.4.1 Dispensing Well Plate for High Throughput Screening . 3.4.2 TopSpot print heads for High Throughput Fabrication of Microarrays . 4. Conclusion. 5. References. DNA BASED BIO-MICRO-ELECTRONIC MECHANICAL SYSTEMS 1. Introduction. 1.1 The unique features of nucleic acids. 1.2 Lab on the Chip. 1.2.1 Electrophoresis. 1.2.2 Polymerase Chain Reaction (PCR). 1.3 Biochemical reaction chains for integration: biosensors and the lab biochip . 2. Microarrays and Biochips based on DNA. 2.1 The typical microarray experiment. 2.2 Manufacturing of Microarrays. 2.2.1 Synthesis on the chip. 2.2.2 Spotting techniques. 2.3 Transcription Analysis. 2.4 Oligonucleotide Arrays for sequencing. 2.5 Active arrays. 2.5.1 Enzymes acting on immobilised DNA. 2.5.2 PCR on the Chip. 2.6 Integrated PCR. 2.6.1 Micro-chamber Chips. 2.6.2 Micro-fluidic Chips. 3. Nano-biotechnology: DNA as material. 3.1 DNA directed immobilisation and
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