Assessing Heterogeneity in Clinical Trials Using The Frailty Model 9783639213348

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Various approaches are discussed to fit such a frailty model, and a Bayesian approach based on the Laplace approximation is detailled. We illustrate this research using data from an EORTC multicenter clinical trial for breast cancer and from a pooled database of seven EORTC clinical trials in bladder cancer patients.
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