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About this product
- PublisherSpringer-Verlag New York Inc.
- Date of Publication26/09/2011
- GenreClinical Medicine: Professional
- Series TitleCancer Treatment and Research
- Series Part/Volume Number51
- Place of PublicationNew York
- Country of PublicationUnited States
- ImprintSpringer-Verlag New York Inc.
- Content Notebiography
- Weight747 g
- Width155 mm
- Height235 mm
- Spine25 mm
- Edited byDavid M. Goldenberg
- Edition StatementSoftcover reprint of the original 1st ed. 1990
- Table Of ContentsI. Historical and Theoretical Perspectives.- 1. Clinical radioimmunodetection: The second decade.- 2. Antibody targeting: Theoretical considerations.- II. Model Systems.- 3. Experimental model systems for antibody targeting and radioimmunodetection.- 4. Preclinical models and methods for the study of radiolabeled monoclonal antibodies in cancer diagnosis and therapy.- 5. Physiology of monoclonal antibody accretion by tumors.- 6. Intraperitoneal delivery of monoclonal antibodies.- III. Radiochemistry.- 7. Chelates and antibodies: Current methods and new directions.- 8. Radiolabeling antibodies via the cyclic anhydride of DTPA - Experiences of 5 years.- 9. Bifunctional chelating agents for radiometal-labeled monoclonal antibodies.- 10. Optimization of biodistribution by introducing different chemical linkages between antibody and an indium-111 chelate.- 11. Novel bifunctional linkers for antibody chelation with radiometals.- 12. Labeling of anti-tumor antibodies and antibody fragments with Tc-9m.- IV. Clinical Studies.- 13. Requirements for the use of radioimmunodetection of cancer in clinical practice.- 14. In-vivo antibody imaging for the detection of human tumors.- 15. In-111 monoclonal antibody immunoscintigraphy of colorectal cancer.- 16. Tumor targeting with monoclonal antibody B72.3: Experimental and clinical results.- 17. Antibody imaging of endocrine tumors.- 18. Diversity of the human immune response to clinically used murine monoclonal antibodies.- V. New Approaches.- 19. Antibody lymphoscintigraphy.- 20. Radioimmunoguided surgery: A new intraoperative approach to the detection of tumor.- 21. Augmentation of tumor antigen expression by recombinant human interferons: Enhanced targeting of monoclonal antibodies to carcinomas.- 22. Anti-antibody enhancement of tumor imaging.
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