63 black & white illustrations, 11 colour illustrations, 36 black & white tables
Debasis Bagchi, Sashwati Roy, Siba P. Raychaudhuri
Unsewn / adhesive bound
Table Of Contents
SECTION I Systems Biology of Inflammation and Regulatory Mechanisms At the Interface between Acute and Chronic Inflammation: Insights from Computational Modeling Yoram Vodovotz Inflammation in Health and Disease: A Robust, Adaptive, Multiscale System Inflammation Is a Complex System with Context-Dependent Regulation: Insights from Computational Modeling From Wound Healing to Cancer: Modeling Interrelationships among Acute Inflammation, Chronic Inflammation, and Cancer From Modeling to Rational Reprogramming of Inflammation Summary: Clinical and Basic Science Perspectives Conclusions and Future Directions Take-Home Messages Acknowledgments References The Cellular Component of Chronic Inflammation Julie Roda and Tim Eubank What is Chronic Inflammation? The Cellular Component of Chronic Inflammation Take-Home Messages References Mast Cells in Chronic Inflammation Traci A. Wilgus and Brian C. Wulff Mast Cell Biology Physiological Functions Pathological Role in Chronic Inflammatory Diseases Conclusions and Future Directions Take-Home Messages References Hypoxia and Hypoxia-Inducible Factor in Inflammation Kiichi Hirota Inflammation Interaction between Hypoxic Environment and Inflammation Canonical Signaling Pathway to Hypoxia-Inducible Factor Activation Oxygen Tension-Independent Activation of HIF Cross Talk between NF-kappaB and HIF Immunocompetent Cells and HIF Impact of Anti-Inflammatory Drugs on HIF Activity Inflammatory Disorders and HIF Conclusions and Future Directions Take-Home Messages References Bioactive Phospholipid Mediators of Inflammation Sainath R. Kotha, Jordan D. Secor, Smitha Malireddy, and Narasimham L. Parinandi Salient Features of Inflammation Mediators of Inflammation Phosphatidic Acid (PA) as a Bioactive Phospholipid Mediator of Inflammation Lysophosphatidic Acid (LPA) as a Bioactive Phospholipid Mediator of Inflammation Conclusions and Future Directions Take-Home Messages Acknowledgements References Hematopoietic Stem Cells in Atherosclerotic Development and Resolution Reeva Aggarwal, Vincent J. Pompili, and Hiranmoy Das Introduction HSC Regulation of Self-Renewal Differentiation of HSCs Development of Atherosclerosis Therapies for Atherosclerosis Development of Ischemia and Therapy Conclusions and Perspectives Take-Home Messages Acknowledgments References Inflammation as a Confounding Factor in Regenerative Medicine Myron Allukian and Kenneth W. Liechty Inflammation Cells Extracellular Matrix Conclusions and Future Directions Take-Home Points References NOx in the CNS: Inflammation and Beyond Annadora J. Bruce-Keller NOx History and Structure Cell Type Specific Expression and Function in Brain Physiologic Mechanisms of NOx Signaling Conclusions and Unanswered Questions Take-Home Messages References Resolution of Inflammation Amitava Das and Sashwati Roy Introduction Cascades of Wound Healing Resolution of Inflammation Role of Micrornas in Inflammation Linking Micrornas and Lipid Mediators in Resolution of Inflammation Take-Home Messages References H2S in Inflammation Hyun-Ock Pae and Hun-Taeg Chung Introduction Dynamic Interplay of H2S with NO and CO in Inflammatory Conditions Janus Face of H2S: Its Pro-Inflammatory and Anti-Inflammatory Effects Perspectives Take-Home Messages Acknowledgements References SECTION II Pathologies Associated with Inflammation Is There a Connection between Inflammation and Oxidative Stress? Chandrakala Aluganti Narasimhulu, Xueting Jiang, Zhaohui Yang, Krithika Selvarajan, and Sampath Parthasarathy Introduction Atherosclerosis Oxidative Stress and Atherosclerosis Inflammation and Atherosclerosis Would Anti-Inflammatories and Antioxidants Prevent Atherosclerosis? Conclusions Take-Home Messages Acknowledgements References Chronic Inflammation and Cancer: A Matter of Lifestyle Subash C. Gupta, Ji Hye Kim, Sahdeo Prasad, and Bharat B. Aggarwal What Is Inflammation? Regulation of Inflammation at the Molecular Level Lifestyle Factors That Activate Inflammation How Inflamma
Sashwati Roy, PhD, is an Associate Professor in the Department of Surgery and Director, Laser Capture Molecular Core in the College of Medicine, Ohio State University, Columbus. Debasis Bagchi, PhD, is a Professor in the Department of Pharmacological and Pharmaceutical Sciences at University of Houston, Texas. His research interests include free radicals, human diseases, carcinogenesis, pathophysiology, mechanistic aspects of cytoprotection by antioxidants, regulatory pathways in obesity, and gene expression. Siba P. Raychaudhuri, MD, is the Chief of the Rheumatology Division at the VA Medical Center in Sacramento, California, and a Clinical Assistant Professor in the Division of Rheumatology, Allergy and Clinical Immunology at the University of California, Davis. Dr. Raychaudhuri's major research focus is to understand the molecular mechanisms of immune-mediated inflammatory diseases.