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70 Illustrations, black and white; XII, 502 p. 70 illus.
K. W. Miller, S. H. Roth
Softcover reprint of the original 1st ed. 1986
Table Of Contents
I. Cellular Actions of Anesthetics.- 1. Cellular and Synaptic Effects of General Anesthetics.- 2. Barbiturate and Benzodiazepine Actions on Mouse Neurons in Cell Culture.- 3. Postsynaptic Actions of Pentobarbital in Cultured Mouse Spinal Neurons and Rat Hippocampal Neurons.- 4. Selective and Differential Effects of Barbiturates on Neuronal Activity.- 5. Putative Capacitance Increase in Hippocampal CAl Cells following Ethanol Application.- 6. General Anesthetics and Intracellular Free Calcium Ions.- 7. Actions of Local Anesthetics on Identified Leech Neurons.- 8. Effects of Isoflurane on some Passive and Active Electrical Properties of Trigeminal Sensory Neuronsin Vivo.- II. Postsynaptic Actions of Anesthetics.- 9. An Approach to Anesthetic Action from Studies of Acetylcholine Receptor Function.- 10. Interactions of Local Anesthetics with Torpedo Nicotinic Acetylcholine Receptors.- 11. General Anesthetics Act Both Specifically and Nonspecifically on Acetylcholine Receptors.- 12. The Influence of Anesthetics on Postsynaptic Ion Channels.- 13. Mechanism of Nicotinic Channel Blockade by Anesthetics.- 14. Barbiturate Enhancement of ?-Aminobutyric Acid Receptor Binding and Function as a Mechanism of Anesthesia.- 15. Barbiturate-Sensitive Sites in the Benzodiazepine-GABA Receptor-Ionophore Complex.- III. Anesthetics and Sodium Channels.- 16. An Overview of the Mechanisms of Local Anesthetic Action Past, Present, and Future.- 17. Lidocaine Block of Sodium Channels in Heart Cells.- 18. The Kinetic Basis for Phasic Local Anesthetic Blockade of Neuronal Sodium Channels.- 19. Single-Channel Analysis of the Action of Na Channel Blockers 9-Aminoacridine and QX-314 in Neuroblastoma Cells.- 20. Inhibition of Voltage-Sensitive Sodium Channels by Local Anesthetics and Anticonvulsants: A Biochemical and Electrophysiological Analysis.- IV. Biophysical Mechanisms of Anesthetics.- 21. Inside the Black Box .- 22. The Action of Nonionic Anesthetic Substances on Voltage-Gated Ion Conductances in Squid Giant Axons.- 23. Solubility of Volatile Hydrocarbons in Lipid Bilayers: A New Perspective.- 24. The Influence of Anesthetics on the Structure and Thermal Properties of Saturated Lecithins.- 25. Molecular Details of Anesthetic-Lipid Interaction as Seen by Nuclear Magnetic Resonance.- 26. Do Direct Protein/Anesthetic Interactions Underlie the Mechanism of General Anesthesia?.- V. Pressure-Anesthetic Interactions.- 27. Homogeneous and Branching Axons: Differing Responses to Anesthetics and Pressure.- 28. New Observations on the Mechanism of Pressure-Anesthetic Interactions.- 29. Modification of Pressure and Anesthesia Tolerance by Multiday Exposures to High-Pressure Heliox or to Subanesthetic Levels of General Anesthetics.- 30. Pressure Reversal of Halothane's Antiviral Action: Effect of Halothane and Pressure on Measles Vims Protein Synthesis.- VI Toxicity of Local Anesthetics.- 31. Potentially Toxic Actions of Local Anesthetics in Cardiac Tissue.- 32. Modulated Receptor Theory and Cardiac Toxicity of Local Anesthetics.- 33. Toxicity of Intravenously Administered Local Anesthetic Agents in the Dog: Cardiovascular and Central Nervous System Effects.- 34. Local Anesthetic Effects on Myocardial Excitation-Contraction Coupling.- VII Toxicity of General Anesthetics.- 35. Anesthetic-Induced Hepatotoxicity in the Hyperthyroid Rat.- 36. Role of Oxygen Availability to the Liver in Anesthesia-Induced Hepatotoxicity.- 37. Pathogenic Mechanisms for Halothane Hepatotoxicity in Animal Models and Man.- 38. Evidence for a Role in the Immune System in the Pathogenesis of Halothane Hepatitis.- Appendix: Tables of Physical and Pharmacological Properties of Anesthetics.- Contributors.