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About this product
- Date of Publication26/09/2011
- Series TitleDevelopments in Cardiovascular Medicine
- Series Part/Volume Number104
- Place of PublicationDordrecht
- Country of PublicationNetherlands
- Content Note440 p.
- Weight676 g
- Width155 mm
- Height235 mm
- Edited byH.M. Piper
- Edition StatementSoftcover reprint of the original 1st ed. 1990
- Table Of ContentsI: Introduction.- 1. Irreversible ischemic injury: definition of the problem.- 2. Recovery of severely ischemic myocardium: a challenge for the clinical cardiologist.- II: The Role of Energy Deficiency.- 3. The critical ATP threshold hypothesis.- 4. Importance of glycolytically produced ATP for the integrity of the threatened myocardial cell.- III: The Search for Critical Cellular Structures.- 5. Loss of sarcolemmal integrity in ischemic myocardium.- 6. Mitochondrial injury in the oxygen-depleted and reoxygenated myocardial cell.- 7. Lysosomal integrity in ischemic, hypoxic and recovering heart.- IV: The Role of Lipids.- 8. Detrimental effects of fatty acids and their derivatives in ischemic and reperfused myocardium.- 9. Hydrolysis of phospholipids and cellular integrity.- 10. Eicosanoids and the ischemic myocardium.- V: The Role of Oxygen Radicals.- 11. Importance of free radicals generated by endothelial and myocardial cells in ischemia and reperfusion.- 12. The role of leukocytes in ischemic damage, reperfusion injury and repair of the myocardium.- 13. Problems associated with reperfusion of ischemic myocardium.- VI: The Role of Calcium.- 14. Subcellular calcium shifts in ischemia and reperfusion.- 15. Causes and effects of changes in cytosolic free calcium in the hypoxic myocardial cell.- VII: Mechanical Factors: Rigor and Contracture.- 16. Rigor and contracture, the role of phosphorus compounds and cytosolic calcium.- 17. Importance of mechanical factors in ischemic and reperfusion injury.- VIII: The Role of Endothelial Cells and Neurons.- 18. Sensitivity of the endothelium to hypoxia and reoxygenation.- 19. Release and effects of catecholamines in myocardial ischemia.- IX: Conclusions.- 20. Severe ischemic myocardial injury: Perspectives for therapy.
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