144 black & white illustrations, 14 black & white tables
3rd Revised edition
Table Of Contents
Measuring Toxicity and Assessing Risk Introduction Chemistry of Toxicants Toxicity Testing Methods Factors to be Considered in Planning Toxicity Testing The LD50 (Median Lethal Dose) Experiment No Observed Adverse Effect Levels Mixtures Toxicity, Hazard, and Risk Case Study: Risk, Perception, and Vaccination Bibliography Toxicokinetics Introduction Absorption Distribution Elimination Toxicokinetic Models Contrasting Kinetics of Lipophilic Substances Bibliography Biotransformation Introduction Primary Biotransformation (Phase I Reactions): Hydrolysis Primary Biotransformation (Phase I Reactions): Oxidation Primary Biotransformation (Phase I Reactions): Reduction Secondary Metabolism (Phase II Reactions) Factors that Influence Metabolism Bibliography Cellular Sites of Action Introduction Interaction of Toxicants with Proteins Effects of Toxicants on Lipids Effects of Toxicants on Nucleic Acids Mechanisms of Cell Death Case Study: Cyclooxygenase Inhibitors Bibliography Genomics and New Genetics in Toxicology Introduction The Human Genome Project Toxicogenomics Metabolomics Personalized Susceptibility and Tailored Therapeutics Race, Ethics, and Genomics Systems Toxicology Case Study: Using GenBank and Online Tools in Genomics Bibliography Carcinogenesis Cancer The Epidemiology of Cancer Carcinogenesis Oncogenes and Tumor Suppressor Genes Chemical Carcinogens: Initiation Chemical Carcinogens: Promotion Protection against the Development of Cancer Testing Compounds for Carcinogenicity Critiques of Strategies in Cancer Research Carcinogenesis: A Complex Process Case Study: Predicting Carcinogenesis Based upon Chemistry (QSAR) Bibliography Reproductive Toxicology and Teratology Introduction Basic Processes in Reproduction and Development: Cell Division The Male Reproductive System The Female Reproductive System The Effects of Toxicants on the Male and Female Reproductive Systems The Process of Development Embryogenesis and Developmental Genetics Effects of Toxicants on Development: Teratogens and Teratogenesis Testing for Reproductive and Developmental Toxicity Case Study: Thalidomide Bibliography Respiratory Toxicology Function of the Respiratory System Anatomy and Physiology of the Respiratory System Pulmonary Ventilation Effects of Toxicants on the Respiratory System: General Principles Defense Mechanisms of the Respiratory System Exposure to Respiratory Toxicants Immediate Responses to Respiratory Toxicants: Mechanisms Immediate Responses to Respiratory Toxicants: Effects on Upper and Lower Airways Delayed and Cumulative Responses to Respiratory Toxicants Inhalation Studies Case study: Nanoparticles Bibliography Cardiovascular Toxicology Function of the Cardiovascular System Anatomy and Physiology of the Heart Effects of Toxicants on the Heart The Vascular System Effects of Toxicants on the Vascular System The Blood Effects of Toxicants on the Blood Effects of Toxicants on Platelets and Coagulation Bibliography Neurotoxicology Function of the Nervous System Anatomy and Physiology of the Nervous System Effects of Toxicants on the Nervous System: General Principles Effects of Toxicants on the Nervous System: General Categories Effects of Toxicants on Electrical Conduction Effects of Toxicants on Synaptic Function Axonopathies Myelinopathies Effects of Toxicants Directly on Neurons and Glial Cells Other Neurotoxicants Effects on Special Sensory Organs Developmental Effects Methods in Neurotoxicology Case Study: Botulinum Toxin Bibliography Hepatic Toxicology Anatomy and Physiology of the Liver Function of the Liver Types of Toxicant-Induced Liver Injury Response to Liver Injury Evaluating Liver Injury and Treating Disease Case Study: Reye's Syndrome Bibliography Renal Toxicology Function of the Kidneys Anatomy and Physiology of the Kidneys Effects of Toxicants on the Kidney: General Principles Damage
Karen E. Stine, PhD, is a professor of Biology and former dean of the School of Sciences at Auburn University at Montgomery in Alabama, USA. She has also served as the director of the undergraduate toxicology program at Ashland University in Ohio. She earned her PhD in toxicology from the University of North Carolina at Chapel Hill. Dr. Stine is a member of the Society of Toxicology and the Society of Environmental Toxicology and Chemistry. At Clemson University, Dr. Stine co-developed and co-taught a Principles of Toxicology course that was open to both undergraduate and graduate students. Her research interests are in the area of mechanisms of toxicity and focus on the role of stress proteins in cellular function and dysfunction. Dr. Stine has also authored or co-authored several research publications in the field of toxicology. Thomas Miller Brown, PhD, is president of Genectar Com LLC in Whitefish, Montana, USA which conducts research in toxicology, genetics, and genomics, now focusing on pigment cell development in the common wood nymph butterfly as a melanoma model. He earned his PhD from Michigan State University. Formerly a professor, Dr. Brown taught Toxicology of Insecticides, Principles of Toxicology, and Insect Biotechnology. He also led the discovery of an actively transposing short interspersed nuclear element (Insect Science 16:219-226). He has published papers on the biochemical toxicology of organophosphorus compounds and on the mechanisms of insecticide resistance in insects. Dr. Brown has also conducted research at Nagoya University and Tsukuba Science City in Japan.