Diamond and Mica have been best friends since primary school and have always watched each other's backs, but after Mica moves out of their drug-infested neighbourhood, they have a scandalous falling-out and lose touch. When Diamond hooks up with Kemp Lo - one of North Philly's most notorious drug dealers - she too is able to leave the hood. Under extreme circumstances, Mica and Diamond meet up and are back on the map as the Laverne and Shirley of the ghetto - but both women have alterior motives for rekindling their friendship.