Please note that the content of this book primarily consists of articles available from Wikipedia or other free sources online. Prairie du Chien is a city in and the county seat of Crawford County, Wisconsin, United States. The population was 6,018 at the 2000 census. Often referred to as Wisconsin's second oldest city, Prairie du Chien was established by French voyageurs in the late seventeenth century. The city is located near the confluence of the Wisconsin and Mississippi Rivers, a strategic point along the Fox-Wisconsin Waterway that connects the Great Lakes with the Mississippi.