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Item specifics

Condition
New: A new, unread, unused book in perfect condition with no missing or damaged pages. See the ...
PublishedOn
1982-01-01
Title
Immunological Aspects of Liver Disease
ISBN
9783540113102
Publication Year
1982
Type
Textbook
Format
Paperback
Language
English
Publication Name
Immunological Aspects of Liver Disease
Item Height
244mm
Author
H.C. Thomas, H.J. Mueller-Eberhard, P. A. Miescher
Publisher
Springer-Verlag Berlin AND Heidelberg Gmbh & Co. KG
Item Width
170mm
Subject
Medicine
Item Weight
415g
Number of Pages
210 Pages

About this product

Product Information

Howard C. Thomas In normal subjects the regulatory apparatus of the immune system permits responses to foreign antigens but suppresses those directed to self' components. Autoimmune disease occurs as a failure ofthis system either as a result of a primary defect in the regulatory apparatus (primary autoimmunization) or because of a change in the antigenicity of the tissues (secondary autoimmunization). Autoaggressive reactions are characterised by the presence of autoantibodies. When these are directed to membrane displayed antigens (Fig. 1) they are probably of importance in the lysis of hepatocytes. Those directed to cytoplasmic antigens may be useful diagnostically but are of unknown pathogenic significance. When no extrinsic aetiological factor can be identified, the process is assumed to be the result of a failure ofthe regulatory system, allowing the spontaneous expansion of a clone of autoreactive lymphocytes. The defect may be generalised or specific to certain groups of self-antigens and thus the autoimmune disease may be either multi- or unisystemic. The recent development of techniques to enumerate and measure the functional activity of the suppressor lymphocytes which control the effector limbs of the immune system has enabled investigators to test whether the various purported autoimmune diseases do have as their basis a generalised defect in immunoregu lation. Assessment of antigen-specific immunoregulatory function is, however, not yet readily available. liver Membrane I Antigen (LIM) I Liver I HLA, A, B, C, Sensitisation to Specific -;::!IIIL. .

Product Identifiers

Publisher
Springer-Verlag Berlin AND Heidelberg Gmbh & Co. KG
ISBN-13
9783540113102
eBay Product ID (ePID)
117438677

Product Key Features

Author
H.C. Thomas, H.J. Mueller-Eberhard, P. A. Miescher
Publication Name
Immunological Aspects of Liver Disease
Format
Paperback
Language
English
Subject
Medicine
Publication Year
1982
Type
Textbook
Number of Pages
210 Pages

Dimensions

Item Height
244mm
Item Width
170mm
Item Weight
415g

Additional Product Features

Editor
P. A. Miescher, H.C. Thomas, H.J. Mueller-Eberhard
Country/Region of Manufacture
Germany

Item description from the seller

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WRAP Ltd.
Mubin Ahmed
Unit 4
119 Loverock Road
Reading
Berkshire
RG30 1DZ
United Kingdom
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  • 03800600
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