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Wiley Series in Drug Discovery and Development Ser.: Plant Bioactives and Drug Discovery : Principles, Practice, and Perspectives by Valdir Cechinel-Filho (2012, Hardcover)

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About this product

Product Identifiers

PublisherWiley & Sons, Incorporated, John

ISBN-10047058226X

ISBN-139780470582268

eBay Product ID (ePID)7038265740

Product Key Features

Number of Pages592 Pages

Publication NamePlant Bioactives and Drug Discovery : Principles, Practice, and Perspectives

LanguageEnglish

Publication Year2012

SubjectNaturopathy, Chemistry / Organic

TypeTextbook

Subject AreaHealth & Fitness, Science

AuthorValdir Cechinel-Filho

SeriesWiley Series in Drug Discovery and Development Ser.

FormatHardcover

Dimensions

Item Height1.3 in

Item Weight34.6 Oz

Item Length9.5 in

Item Width6.4 in

Additional Product Features

Intended AudienceScholarly & Professional

LCCN2011-041434

Reviews"In conclusion, this book could be a useful guide not only for PhD students starting their activity in the field of plant metabolites, but also for more advanced researchers looking for a state-of-the-art overview of modern research in this fascinating field." ( ChemMedChem , 1 March 2013)

Dewey Edition23

Series Volume Number17

IllustratedYes

Dewey Decimal615.3/21

Table Of ContentContributors xv Preface xix 1 Natural Products in Drug Discovery: Recent Advances 1 Gordon M. Cragg, Paul G. Grothaus, and David J. Newman 2 Modern Approaches in the Search for New Active Compounds from Crude Extracts of Natural Sources 43 Emerson F. Queiroz, Kurt Hostettmann, and Jean-Luc Wolfender 3 Natural Products as Lead Compounds in Medicinal Chemistry 81 Eliezer J. Barreiro, Carlos A. M. Fraga, and Lidia M. Lima 4 The Importance of Structural Manipulation of Natural Compounds in Drug Discovery and Development 127 Arturo San Feliciano, Mar ía Á. Castro, Jos é L. L ópez-P érez, and Esther del Olmo 5 The Action of Plants and their Constituents on the Central Nervous System 161 F úlvio R. Mendes, Giuseppina Negri, Joaquim M. Duarte-Almeida, Ricardo Tabach, and Elisaldo A. Carlini 6 The Role of Natural Products in Discovery of New Anti-Infective Agents with Emphasis on Antifungal Compounds 205 Maximiliano Sortino, Marcos Derita, Laura Svetaz, Marcela Raimondi, Melina Di Liberto, Elisa Petenatti, Mahabir Gupta, and Susana Zacchino 7 Antiulcer Agents from Higher Plants 241 Luiz C. Klein-J únior, Jos é R. Santin, and S érgio F. de Andrade 8 Recent Progress in the Chemistry and Biology of Paclitaxel (TaxolTM) and Related Taxanes 263 Jun Qi, Jielu Zhao, and David G. I. Kingston 9 Cancer Chemopreventive Activity of Higher Plants 337 A. Douglas Kinghorn, Yulin Ren, Jie Li, and Chung Ki Sung 10 Medicinal Plants and Pharmaceutical Technology 359 Ruth M. Lucinda da Silva, Ang élica G. Couto, and Tania M.B. Bresolin 11 Natural Products in Clinical Trials 395 Sigrun Chrubasik 12 The Influence of Biotic and Abiotic Factors on the Production of Secondary Metabolites in Medicinal Plants 419 Dayana R. Gouvea, Leonardo Gobbo-Neto, and Norberto P. Lopes 13 Production of Bioactives Compounds: The Importance of Pictet-Spengler Reaction in the XXI Century 453 Pilar Menendez, Ilaria D'Acquarica, Giuliano Delle Monache, Francesca Ghirga, Andrea Calcaterra, Marco Barba, Alberto Macone, Alberto Boffi, Alessandra Bonamore, and Bruno Botta 14 Screening Methods for Drug Discovery from Plants 489 Alan L. Harvey 15 Phytotherapeutics - Intellectual Property Rights, Global Market, and Global Regulatory Guidelines 499 James D. McChesney, Raymond Cooper, and Kip Vought 16 Cooperation Between the Pharmaceutical Industry and Academic Institutions in Drug Discovery 529 Valdir Cechinel-Filho, Rivaldo Niero, and Rosendo A. Yunes Acknowledgments 542 References 542 Index 545

SynopsisAn in-depth exploration of the applications of plant bioactive metabolites in drug research and development Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today. With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications. Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields., Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, this book overviews plant biodiversity as a source of new drugs and drug discovery strategies.

LC Classification NumberQV 766