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Formulation and Evaluation of Buspirone Hydrochloride Buccal Films by Vandana...

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eBay item number:165774428711

Item specifics

Condition
New: A new, unread, unused book in perfect condition with no missing or damaged pages. See the ...
ISBN
9783844315851

About this product

Product Identifiers

Publisher
LAP Gmbh & Company KG
ISBN-10
3844315853
ISBN-13
9783844315851
eBay Product ID (ePID)
122828119

Product Key Features

Number of Pages
148 Pages
Language
English
Publication Name
Formulation and Evaluation of Buspirone Hydrochloride Buccal Films
Subject
Textiles & Polymers, Materials Science / General, Spectroscopy & Spectrum Analysis, Psychopathology / Anxieties & Phobias, Pharmacology, Chemistry / General
Publication Year
2011
Type
Textbook
Author
Roopa Karki, Vandana Chaudhary, Upendra Nagaich
Subject Area
Technology & Engineering, Science, Psychology, Medical
Format
Trade Paperback

Dimensions

Item Height
0.3 in
Item Weight
8 Oz
Item Length
9 in
Item Width
6 in

Additional Product Features

Synopsis
Buspirone Hydrochloride is used in the treatment of anxiety. It has a short half life and low oral bioavailability of 5%. Therefore, the purpose of this research was to develop unidirectional Bucco- adhesive films of Buspirone Hydrochloride by solvent casting technique using full factorial designs. HPMC K15M and Eudragit RL-100 were used as polymers in different proportion. Polyethylene glycol 400 was used as plasticizer and Sodium lauryl sulphate was used as permeation enhancer in different concentration. The physicochemical compatibility of the drug and the polymers was studied by FT-IR spectroscopy. The results suggested no physicochemical incompatibility between the drug and the polymers. In full factorial designs, total amount of polymer (X1) and percentage of HPMC K15M (X2) was kept as a independent variables. After wards, statistically optimization process was carried out and two optimized formulation (OF1 and OF2) was developed. The results of optimization formulation showed greater degree of % similarity with predicted values. Stability studies of two optimized formulations were carried out at room temperature as per ICH Q1C guidelines.

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