Reviews
Concepts in Clinical Pharmacokinetics, 6th Edition William J. Spruill, William E. Wade, Joseph T. DiPiro, Robert A. Blouin, Jane M. Pruemer , , , The Pharmaceutical Journal, Vol. 29.3, No. 7818, July 12, 2014 [REVIEWER'S EXPERT OPINION] Laurence A. Goldberg This book introduces pharmacokinetic and biopharmaceutic principles , including relevant terminology and calculations. Most of the material relates to the individualization of drug dosing regimens. The book sets out to teach tile basic biopharmaceutical concepts, mathematical models and clinical applications needed to determine values such as close, interval and steady-state concentration. It aims to provide the student or healthcare practitioner with the knowledge required to understand better this complicated yet vitally important subject. It is organized into 15 lessons (chapters), some relating to individual drugs such as aminoglycosides, vancomycin, theeophylline, phenytoin and digoxin and others are based on concepts such as two-compartment models, drug distribution and protein binding. Eleven of the lessons include practice quizzes designed to chart progress and four lessons are completely devoted to clinical cases. The first lessons include pharmacokinetic and pharmacodynamic principles, as well as an overview of biopharmaceutic principles. Each of these lessons begins with a list of educational objectives and concludes with a series of self -assessment review questions. Answers and feedback for incorrect responses are provided for these short answer questions. Discussion points, intended for group discussion, complement each lesson. Lessons 12 to 15 present brief patient case studies with aminoglycosides, theophylline, vancomycin, digoxin and phenytoin so the tile reader can practice using pharmacokinetic equations. After completing tile basic pharmacokinetics lesson, for example, the reader should be able to define the concept of apparent volume of distribution and the components of body fluids that make up extracellular and intracellular fluid, define drug clearance and describe tile difference between first- and zero-order elimination and how each appears graphically. Similarly, the reader should be able to calculate the elimination rate constant, define half -life, calculate a drug's half-life, define the relationship between half -life and elimination rate constant, define drug clearance, and when given plasma concentration data after an intravenous bolus dose of a drug, be able to calculate a drug's volume of distribution, concentration at time zero and AUC. Pharmacy students and busy practitioners wishing to come to terms with pharmacokinetic calculations and wanting to illustrate pharmacokinetic principles in graphic form will find this book of immense value.
Synopsis
This text has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This sicth edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers., The very popular volume simplifies a complex subject using carefully designed conceptual approaches to make pharmacokinetics understandable for all students and pharmacists. The sixth edition is thoroughly review, revised, and redesigned to enhance the reader's grasp of the material., Concepts in Clinical Pharmacokinetics has helped thousands of students and practitioners through five editions by simplifying a complex subject. The authors have thoroughly reviewed, revised, and redesigned the text to enhance the reader's grasp of the material. This 6th Edition offers a superior approach to understanding pharmacokinetics through extensive use of clinical correlates, figures, and questions and answers. Inside you will find: Content broken into 15 easy-to-follow lessons, perfect for a semester. Practice quizzes in 11 chapters to chart progress. Four chapters completely devoted to clinical cases. More information on hemodialysis More on pharmacogenetics More on plasma concentration versus time curve (AUC) calculations A phenytoin ""cheat sheet"" to help you through the calculations maze New vancomycin cases based on higher desired vancomycin levels and trough-only dose estimations More on modified diet in renal disease (MDRD) formula versus Cockcroft-Gault (CG) formula methods More theory and problems on extended interval aminoglycosides.
