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Lactoferrin and its Role in Wound Healing - 9789400792029
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Located in: Aldershot, United Kingdom
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eBay item number:285354644576
Item specifics
- Condition
- Book Title
- Lactoferrin and its Role in Wound Healing
- ISBN
- 9789400792029
- Publication Year
- 2013
- Type
- Textbook
- Format
- Paperback
- Language
- English
- Publication Name
- Lactoferrin and Its Role in Wound Healing
- Item Height
- 235mm
- Publisher
- Springer
- Item Width
- 155mm
- Subject
- Medicine, Chemistry, Biology, Psychiatry
- Item Weight
- 195g
- Number of Pages
- 108 Pages
About this product
Product Information
Lactoferrin is an iron-binding glycoprotein belonging to the transferrin family. It acts as a defense in host animals against microbes and viruses, since it has a broad spectrum of antimicrobial and antiviral activities. Lactoferrin has been shown to regulate the growth and differentiation of many types of cells. The results of recent studies indicate that lactoferrin is a potent regulator of dermal fibroblasts, and promotes cutaneous wound healing. The collagen gel contraction, a model of wound contraction during wound healing process, and migration of human fibroblasts were enhanced by lactoferrin. LRP-1 (LDL Receptor related Protein-1) acts as a signaling receptor for lactoferrin that mediate fibroblast response to lactoferrin by activating ERK/MAPK signaling pathway. In addition, lactoferrin promotes biosynthesis of extracellular matrix (ECM) component such as type-I collagen and hyaluronan. Hyaluronan is a major component of ECM in connective tissue and promotes wound healing. The promoting effect of lactoferrin on hyaluronan production was accompanied by promotion of HAS2 (hyaluronan synthase 2) expression. These observations suggest that lactoferrin promotes the wound healing by providing an ECM that promotes fibroblast migration. Lactoferrin is also known for its anti-inflammatory and immune modulating properties. According to recent in vivo study, lactoferrin promotes wound repair by promoting the early inflammatory phase of wound healing. Based on this, recombinant human lactoferrin was subsequently tested clinically in a Phase II trial in patients with diabetic ulcers and was found to be effective. Lactoferrin should be further evaluated in patients with diabetic and other types of ulcers.
Product Identifiers
Publisher
Springer
ISBN-13
9789400792029
eBay Product ID (ePID)
180826105
Product Key Features
Publication Name
Lactoferrin and Its Role in Wound Healing
Format
Paperback
Language
English
Subject
Medicine, Chemistry, Biology, Psychiatry
Publication Year
2013
Type
Textbook
Number of Pages
108 Pages
Dimensions
Item Height
235mm
Item Width
155mm
Item Weight
195g
Additional Product Features
Country/Region of Manufacture
Netherlands
Item description from the seller
Business seller information
BOOKS ETC LIMITED
Andy Smith
Books Etc, Unit 4
Eastern Road
Aldershot
Hampshire
GU12 4YD
United Kingdom
Value added tax number:
- GB 976952259
Company registration number:
- 06687355
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eBay item number:285354644576
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