Picture 1 of 4
Gallery
Picture 1 of 4
Have one to sell?
Heparanase: From Basic Research to Clinical Applications by Israel Vlodavsky
US $29.99
Approximately£22.66
or Best Offer
Condition:
“Is essentially new in terms of readability but has some scuffs on the cover (see pictures)”
Like New
A book that has been read, but looks new. The book cover has no visible wear, and the dust jacket (if applicable) is included for hard covers. No missing or damaged pages, no creases or tears, no underlining or highlighting of text, and no writing in the margins. May have no identifying marks on the inside cover. No wear and tear. See the seller’s listing for full details and description of any imperfections.
- Buy it nowHeparanase: From Basic Research to Clinical Applications by Israel Vlodavsky
Oops! Looks like we're having trouble connecting to our server.
Refresh your browser window to try again.
Postage:
Free USPS Media MailTM.
Located in: Westerville, Ohio, United States
Delivery:
Estimated between Mon, 4 Aug and Sat, 9 Aug to 94104
Returns:
30 days return. Buyer pays for return postage. If you use an eBay delivery label, it will be deducted from your refund amount.
Payments:
Shop with confidence
Seller assumes all responsibility for this listing.
eBay item number:305178415406
Item specifics
- Condition
- Like New
- Seller notes
- “Is essentially new in terms of readability but has some scuffs on the cover (see pictures)”
- Country/Region of Manufacture
- Israel
- Pages
- 885
- Publication Date
- 2020-04-10
- Book Title
- Heparanase: From Basic Research to Clinical Applications
- ISBN
- 9783030345204
About this product
Product Identifiers
Publisher
Springer International Publishing A&G
ISBN-10
3030345203
ISBN-13
9783030345204
eBay Product ID (ePID)
9038634505
Product Key Features
Number of Pages
Xviii, 885 Pages
Publication Name
Heparanase : from Basic Research to Clinical Applications
Language
English
Publication Year
2020
Subject
Oncology, Research
Type
Textbook
Subject Area
Medical
Series
Advances in Experimental Medicine and Biology Ser.
Format
Hardcover
Dimensions
Item Weight
53.4 Oz
Item Length
9.3 in
Item Width
6.1 in
Additional Product Features
Reviews
"This is a very focused book and would likely be of interest primarily to basic scientists such as biochemists and cell biologists, as well as clinicians with investigative interests in numerous diseases that may involve heparanase in their pathogenesis, such as oncologists, hematologists, and nephrologists. ... This book will be a valuable resource for investigators with interest in heparanase. It represents a 'one-stop' location for data and references on heparanase. I am not aware of other books strictly focused on this subject." (George M Rodgers, Doody's Book Reviews, October 23, 2020)
Series Volume Number
1221
Number of Volumes
1 vol.
Illustrated
Yes
Table Of Content
Section 1: Historical Background.- Chapter 1: Mast cell/platelet heparanase/Heparan sulfate biosynthesis and turnover.- Chapter 2: gene cloning/overview.- Chapter 3: gene cloning/melanoma metastasis.- Chapter 4: gene cloning/cancer/immune system.- Chapter 5: heparin/HS modifying enzymes.- Section 2: Crystal Structure/substrate specificity/gene regulation.- Chapter 6: crystal structure.- Chapter 7: molecular dynamics, KKDC peptide.- Chapter 8: Biochemistry/active site.- Chapter 9: substrate specificity.- Chapter 10: gene regulation, promoter/Egr1/methylation.- Chapter 11: SNPs.- polymorphism.- Chapter 12: Splice variants.- Section 3: Cell & tumor biology (general functions & mode of action).- Chapter 13: Exosomes/heparan sulfate/heparanse.- Chapter 14: Exosomes/drug resistance.- Chapter 15: Nuclear heparanse/transcriptional activity.- Chapter 16: Non-Enzymatic functions/Signal transduction/cellular trafficking/autophagy.- Chapter 17: Heparan sulfate/stem cells/inflammation.- Chapter18: Danger signals/HS/platelet heparanse.- Chapter 19: Heparanse/Intergrins/Melanoma.- Section 3: Immune Cells/Immnuno-Modulation.- Chapter 20: Heparain. Heparanse and Selectins in Cancer Metastasis and Inflamation --- Chapter 21: Trans-Endithelial Migration, Lymphocytes, Neutrophils/T-cells --Chapter 22: Macrophages, dendritic cells, autoimmunity.- Chapter 23: Macrophages, Heparanse and the tumor microenvironment, neutralizing antibodies.- Chapter 24: NK Cells.- Section 4: Cancer (heparanse in specific types of cancer).- Chapter 25: Myeloma, inhbition, drug resistance.- Chapter 26: Breast Cancer/Pancreatic Cancer/Cancer and Inflammation.- Chapter 27: Brain Metastasis/MIR-1258.- Chapter 28: Gastric cancer/immunization.- Chapter 29: Head and Neck Cancer.- Chapter 30: Glioma.- Chapter 31: Sarcoma.- Section 5: Inhibitors/clinical trails/cancer.- Chapter 32: Chemistry/synthesis of heparanse inhibitors PI-88, PG.- Chapter 33: PG series/biology/Tumor models and clinical trial.- Chapter34:Chemically modified heparins/Heparin mimetics.- Chapter 35: Medicinal Chemistry (Ronesparstat/small molecules/clinical trials) - Section 6: Other indications/diseases.- Chapter 36: IBD/inflammation and cancer/diabetes/obesity.- Chapter 37: Immune Diabetes.- Chapter 38 Inflammation, Sepsis/Amyloidosis.- Chapter 39: Kidney dysfunction.- Chapter 40: Fibrosis.- Chapter 41: Viral infection.- Chapter 42: Cariomyocytes/Endothelial cell-cardiomyocyte crosstakl in diabetic cariomyopathy.- Chapter 43: Eye research.- Chapter 44: atheroscelerosis, nuclear localization.- Chapter 45: Yona Nadir (coagulation/tissue factor).- Section 7: Heparanse-2 (Hpa2).- Chapter 46: Hpa2 gene cloning.- Chapter 47: UFS.- urofacial syndrome/peripheral neuropathy.- Chapter 48: Hpa2: tumor suppressor.
Synopsis
Written by internationally recognized leaders in Heparanase biology, the book's eight chapters offer an opportunity for scientists, clinicians and advanced students in cell biology, tumor biology and oncology to obtain a comprehensive understanding of Heparanase's multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications. Proteases and their involvement in cancer progression have been well addressed and documented; however, the emerging premise presented within this book is that Heparanase is a master regulator of aggressive cancer phenotypes and crosstalk with the tumor microenvironment. This endoglycosidase contributes to tumor-mediated remodeling of the extracellular matrix and cell surfaces, augmenting the bioavailability of pro-tumorigenic and pro-inflammatory growth factors and cytokines that are bound to Heparan sulfate. Compelling evidence ties Heparanase with all steps of tumor progression including tumor initiation, growth, angiogenesis, metastasis, and chemoresistance, supporting the notion that Heparanase is an important contributor to the poor outcome of cancer patients and a validated target for therapy. Unlike Heparanase, heparanase-2, a close homolog of Heparanase, lacks enzymatic activity, inhibits Heparanase, and regulates selected genes that promote normal differentiation and tumor suppression. Written by internationally recognized leaders in Heparanase biology, this volume presents a comprehensive understanding of Heparanase's multifaceted activities in cancer, inflammation, diabetes and other diseases, as well as its related clinical applications to scientists, clinicians and advanced students in cell biology, tumor biology and oncology.
LC Classification Number
RC261-271
Item description from the seller
About this seller
LoFi Finds
97.1% positive Feedback•1.3K items sold
Registered as a private sellerThereby, consumer rights stemming from EU consumer protection law do not apply. eBay buyer protection still applies to most purchases.
Seller Feedback (404)
- 2***e (14)- Feedback left by buyer.Past monthVerified purchaseRed ^w^ This thing came quickly, was safely packed, came complete in box as advertised, and was KILLER for the price. Also, RED TRANSLUCENT PLASTIC. I didn't even realize that was an OPTION when I bought it, and yet here we are, with the BEST trend in console design! Getting this was absolutely worth it, and I have been loving it. Absolutely worth a purchase, if you can find one at this price point.
- r***o (289)- Feedback left by buyer.Past monthVerified purchaseItem model inadvertently misidentified in the listing. When it was received, I contacted the seller who immediately refunded my payment. Great customer service!
- l***r (60)- Feedback left by buyer.Past monthVerified purchaseAs described, fast response, fast shipping. Great seller
More to explore:
LoFi Finds
97.1% positive Feedback•1.3K items sold
Registered as a private sellerThereby, consumer rights stemming from EU consumer protection law do not apply. eBay buyer protection still applies to most purchases.
Seller Feedback (404)
- 2***e (14)- Feedback left by buyer.Past monthVerified purchaseRed ^w^ This thing came quickly, was safely packed, came complete in box as advertised, and was KILLER for the price. Also, RED TRANSLUCENT PLASTIC. I didn't even realize that was an OPTION when I bought it, and yet here we are, with the BEST trend in console design! Getting this was absolutely worth it, and I have been loving it. Absolutely worth a purchase, if you can find one at this price point.
- r***o (289)- Feedback left by buyer.Past monthVerified purchaseItem model inadvertently misidentified in the listing. When it was received, I contacted the seller who immediately refunded my payment. Great customer service!
- l***r (60)- Feedback left by buyer.Past monthVerified purchaseAs described, fast response, fast shipping. Great seller