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Molecular Toxicology by P. David Josephy (1996, Hardcover)
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MOLECULAR TOXICOLOGY By P. David Josephy - Hardcover **Mint Condition**.
- Buy it nowMOLECULAR TOXICOLOGY By P. David Josephy - Hardcover **Mint Condition**
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About this product
Product Identifiers
PublisherOxford University Press, Incorporated
ISBN-100195093402
ISBN-139780195093407
eBay Product ID (ePID)62412
Product Key Features
Number of Pages384 Pages
Publication NameMolecular Toxicology
LanguageEnglish
Publication Year1996
SubjectToxicology, General
TypeTextbook
AuthorP. David Josephy
Subject AreaMedical
FormatHardcover
Dimensions
Item Height1 in
Item Weight35.3 Oz
Item Length10.2 in
Item Width7.3 in
Additional Product Features
Intended AudienceCollege Audience
LCCN95-024812
Dewey Edition22
Reviews"A unique textbook in the field of toxicology, as it will give graduate students help in understanding the relationship between biochemical mechanisms and toxicology."--David McMillan, Medical University of South Carolina, "A unique textbook in the field of toxicology, as it will give graduatestudents help in understanding the relationship between biochemical mechanismsand toxicology."--David McMillan, Medical University of South Carolina, "Finally, an affordable graduate-level text that covers most of what Ithink students need to develop a basic understanding of concepts and techniquesused to study mechanisms of action."--Ann DePeyster, M.D., San Diego StateUniversity, Introduction 1. Biochemical Background 2. Molecular Biology and Its Application in Toxicology 3. Biological Oxidations 4. Superoxide and Superoxide Dismutase 5. Hydrogen Peroxide, Catalase, and Peroxidases 6. The Respiratory Burst 7. Lipid Peroxidation 8. Oxidative Stress in the Erythrocyte 9. Introduction to Xenobiotic Metabolism 10. Glucoronide Formation 11. Glutathione and Detoxication 12. Arylamine N-Acetyltransferase 13. Sulfotransferase 14. Cytochrome P-450 15. The AH Receptor and the Toxicity of Chlorinated Aromatic Compounds 16. Identification of DNA Adducts 17. Chemical Mutagenesis 18. Carcinogenesis: The Genetic Targets 19. Polycyclic Aromatic Hydrocarbon Carcinogenesis 20. Aromatic Amines and other N-Aryl Compounds, "Good background text for Mechanisms in Toxicology courses. Individualareas well summarized and reviewed."--Katherine S. Squibb, University ofMaryland at Baltimore, "Good background text for Mechanisms in Toxicology courses. Individual areas well summarized and reviewed."--Katherine S. Squibb, University of Maryland at Baltimore, "Finally, an affordable graduate-level text that covers most of what I think students need to develop a basic understanding of concepts and techniques used to study mechanisms of action."--Ann DePeyster, M.D., San Diego State University
IllustratedYes
Dewey Decimal615.9
Table Of ContentPrefaceAcknowledgments1. Biochemical Background2. Molecular Biology and Its Applications in Toxicology3. Biological Oxidations4. Superoxide and Superoxide Dismutase5. Hydrogen Peroxide, Catalase, and Peroxidases6. The Respiratory Burst7. Lipid Peroxidation8. Oxidative Stress in the Erythrocyte9. Introduction to Xenobiotic Metabolism10. Glucuronide Formation11. Glutathione and Detoxication12. Arylamine N-Acetyltransferase13. Sulfotransferase14. Cytochrome P-45015. The AH Receptor and the Toxicity of Chlorinated Aromatic Compounds16. Identification of DNA Adducts17. Chemical Mutagenesis18. Carcinogenesis: The Genetic Targets19. Polycyclic Aromatic Hydrocarbon Carcinogenesis20. Aromatic Amines and Other N-Aryl Compounds
SynopsisMolecular Toxicology reflects the revolution that toxicology has undergone in the last decade, as the molecular and genetic basis of the science--including drug metabolism, carcinogenesis, programmed cell death, and DNA repair--has been elucidated. It is the first text to explain the principles of toxicology in depth and from the perspective of modern biochemistry and molecular biology, while also providing a sense of the historical development of the science. Emphasizing the latest molecular biological approaches, the book covers xenobiotic biotransformation; reactive intermediates and their interactions with macromolecules; cloning, expression, and analysis of the enzymes of biotransformation; and molecular toxicology of aromatic amines, nitrosamines, polycyclic aromatic hydrocarbons, and chlorinated compounds. The toxicology of oxygen and oxidative stress is also covered in depth. Extensively referenced, up-to-date, and rigorous, Molecular Toxicology is an ideal textbook for advanced undergraduate and graduate courses in molecular and biochemical toxicology, and also serves as a valuable resource for instructors and practicing scientists.
LC Classification NumberRA1220.3.J67 1997
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