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THERAPEUTIC TARGETS OF THE TNF SUPERFAMILY (ADVANCES IN By Iqbal S. Grewal *NEW*
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eBay item number:335350104805
Item specifics
- Condition
- ISBN-10
- 0387895191
- Book Title
- Therapeutic Targets of the TNF Superfamily (Advances in
- Genre
- Immunology
- Item Height
- 10.1 inches
- ISBN
- 9780387895192
- Subject Area
- Medical
- Publication Name
- Therapeutic Targets of the Tnf Superfamily
- Item Length
- 10 in
- Publisher
- Springer New York
- Subject
- Immunology, Oncology, Research, Diseases
- Series
- Advances in Experimental Medicine and Biology Ser.
- Publication Year
- 2009
- Type
- Textbook
- Format
- Hardcover
- Language
- English
- Item Width
- 7 in
- Item Weight
- 22.6 Oz
- Number of Pages
- Xvii, 220 Pages
About this product
Product Information
Tumor necrosis factor (TNF) superfamily is a rapidly growing family of cytokines that interacts with a corresponding superfamily of receptors. Liga- receptor interactions of this superfamily are involved in numerous biological processes ranging from hematopoiesis to pleiotropic cellular responses, including activation, proliferation, differentiation, and apoptosis. The particular response depends on the receptor, the cell type, and the concurrent signals received by the cell. Worldwide interest in the TNF field surged dramatically early in 1984 with the cloning and defining of the profound cellular effects of the first member of this family, TNF . Subsequently, the major influence of TNF on the development and functioning of the immune system was established. Today, over 20 human TNF ligands and their more than 30 corresponding receptors have been identified. Few receptors still remain orphans. What has emerged over the years is that most TNF ligands bind to one distinct receptor and some of the TNF ligands are able to bind to multiple TNF receptors, explaining to some extent the apparent disparity in the number of TNF receptors and ligands. Yet, in spite of some redundancy in TNF ligand/receptor interactions, it is clear that in vivo spatial, temporal, and indeed cell- and tissue-specific expression of both ligands and their receptors are important factors in determining the precise nature of cellular, physiological and pathological processes they control. TNF superfamily has been the most highly investigated area of basic medical research for over two decades.
Product Identifiers
Publisher
Springer New York
ISBN-10
0387895191
ISBN-13
9780387895192
eBay Product ID (ePID)
102803564
Product Key Features
Publication Name
Therapeutic Targets of the Tnf Superfamily
Format
Hardcover
Language
English
Subject
Immunology, Oncology, Research, Diseases
Series
Advances in Experimental Medicine and Biology Ser.
Publication Year
2009
Type
Textbook
Subject Area
Medical
Number of Pages
Xvii, 220 Pages
Dimensions
Item Length
10 in
Item Width
7 in
Item Weight
22.6 Oz
Additional Product Features
LCCN
2008-047209
Intended Audience
Scholarly & Professional
Series Volume Number
647
Number of Volumes
1 Vol.
Lc Classification Number
Qr180-189.5
Table of Content
Overview of TNF Superfamily: A Chest Full of Potential Therapeutic Targets.- Therapeutic Interventions Targeting CD40L (CD154) and CD40: The Opportunities and Challenges.- Targeting TNF for Treatment of Cancer and Autoimmunity.- Targeting of BAFF and APRIL for Autoimmunity and Oncology.- The Role of FasL and Fas in Health and Disease.- OX40 (CD134) and OX40L.- Targeting CD70 for Human Therapeutic Use.- 4-1BB as a Therapeutic Target for Human Disease.- RANK(L) as a Key Target for Controlling Bone Loss.- Targeting the LIGHT-HVEM Pathway.- GITR: A Modulator of Immune Response and Inflammation.- Targeting CD30/CD30L in Oncology and Autoimmune and Inflammatory Diseases.- Tumor Necrosis Factor Receptor Superfamily Member 21: TNFR-Related Death Receptor-6, DR6.- TRAIL and Other TRAIL Receptor Agonists as Novel Cancer Therapeutics.- Therapeutic Potential of VEGI/TL1A in Autoimmunity and Cancer.
Copyright Date
2009
Dewey Decimal
616.07/9
Dewey Edition
22
Illustrated
Yes
Item description from the seller
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Description of item was very accurate. Price and shipping costs were reasonable. Book was minimally packaged but arrived promptly in very good condition . Communication is clear and prompt. Would buy from this seller again.
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Description of item was very accurate. Price and shipping costs were reasonable. Items were well packaged. and arrived promptly in good condition. Communication is clear and prompt. Would buy from this seller again.
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This is the new cover not the old cover (was planning on buying both sets anyways). Fast shipping, nice packaging, reasonably priced, excellent communication. Zuber offered to have the item returned if I was unsatisfied with it. Highly recommend this seller.