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Molecular Basis of Chronic Myeloprolifera
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Condition:
“Book is in good condition with no tears except for highlighting/underlining/notes on some of the ”... Read moreAbout condition
Acceptable
A book with obvious wear. May have some damage to the book cover but the book is still completely intact. The binding may be slightly damaged around the edges but it is still completely intact. May have some underlining and highlighting of text and some writing in the margins, but there are no missing pages or anything else that would compromise the readability or legibility of the text. See the seller’s listing for full details and description of any imperfections.
- Buy it nowMolecular Basis of Chronic Myeloproliferative Disorders Petrides Pahl Springer
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US $6.29 (approx £4.68) USPS First Class®.
Located in: Big Pine, California, United States
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Estimated between Tue, 12 Aug and Fri, 15 Aug to 94104
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eBay item number:354383076101
Item specifics
- Condition
- Acceptable
- Seller notes
- Book title
- Molecular Basis of Chronic Myeloproliferative Disorders
- ISBN
- 9783540224853
About this product
Product Identifiers
Publisher
Springer Berlin / Heidelberg
ISBN-10
3540224858
ISBN-13
9783540224853
eBay Product ID (ePID)
45706666
Product Key Features
Number of Pages
Xii, 218 Pages
Publication Name
Molecular Basis of Chronic Myeloproliferative Disorders
Language
English
Publication Year
2004
Subject
Hematology, Oncology, Endocrinology & Metabolism
Type
Textbook
Subject Area
Medical
Format
Hardcover
Dimensions
Item Weight
39.5 Oz
Item Length
9.3 in
Item Width
6.1 in
Additional Product Features
Intended Audience
Scholarly & Professional
LCCN
2004-111462
Dewey Edition
22
Number of Volumes
1 vol.
Illustrated
Yes
Dewey Decimal
616.4/107
Table Of Content
Basics.- 1 Introduction: Towards a Molecular Classification of Chronic Myeloproliferative Disorders.- 2 Chronic Myeloproliferative Disorders: A Clinician's View.- 3 Chronic Myeloproliferative Disorders: A Pathologist's View.- 4 Cytogenetics of Myeloproliferative Disorders.- Polycythemia Vera.- 5 Classification and Molecular Biology of Polycythemias (Erythrocytoses).- 6 Characterization of PRV-1, a Novel Hematopoietic Cell Surface Marker Overexpressed in Polycythemia Rubra Vera.- 7 Impaired Expression of the Thrombopoietin Receptor, Mpl, in Polycythemia Vera.- 8 Growth Factor Signaling in Polycythemia Vera Cells: Specific Hypersensitivities to Cytokines in the Chronic Myeloproliferative Disorders.- 9 Role of the Antiapoptotic Protein Bcl-xL in the Pathogenesis of Polycythemia Vera.- 10 Involvement of Chromosome 9 and 11 in Familial and Sporadic Polycythemia Vera.- Essential Thrombocythemia.- 11 Essential Thrombocythemia: Regulation of Megakaryocytopoiesis.- 12 Hereditary Thrombocythemia.- 13 Thromboembolic Complications in Essential Thrombocythemia: the Role of the Analysis of the Platelet Proteome.- 14 Clonality Studies in Essential Thrombocythemia.- 15 Molecular and Preclinical Aspects of Anagrelide Action.- Chronic Idiopathic Myelofibrosis.- 16 Prolactin-like Protein E and Megakaryocytopoiesis.- 17 Pathophysiology and Stem Cell Biology in Myelofibrosis with Myeloid Metaplasia.- 18 Transforming Growth Factor ß1 in Myelofibrosis.- 19 Idiopathic Myelofibrosis: Evidence for Pathological Crosstalk Between Polymorphonuclear Leukocytes and Megakaryocytes.- Mastocytosis.- 20 C-kit and Mastocytosis.- 21 Tryptases, a Marker of Occult Mastocytosis.- Hypereosinophilic Syndrome.- 22 Familial Hypereosinophilic Syndrome.- 23 Mononuclear Cell Preparations from Patients withIdiopathic Hypereosinophilic Syndromes Do Not Express the Wilms' Tumor Gene.- 24 Clonality Analysis and Hypereosinophilia.- 25 Clonal Lymphocytes in Patients with Idiopathic Hypereosinophilic Syndrome.
Synopsis
Since the first description of Philadelphia chromosome-negative chronic myeloproliferative disorders more than 100 years ago, the diagnosis and therapy of these conditions have been based primarily on clinical experience and judgement. Until recently very little was known about the molecular basis of these diseases. In order to spark research in this area basic scientists and clinicians from various parts of the world have contributed to this volume, the first of its kind to put together the current knowledge. The book deals with the new WHO classification of these disorders, novel aspects of diagnostic pathology, the search for disease-relevant genes utilizing molecular biology and proteomic techniques, the description of the roles of PVR-1 and VHL genes for polycythemias and the discovery of the gene mutation responsible for the idiopathic hypereosinophilic syndrome. A chapter on anagrelide, an important novel drug for the treatment of primary thrombocythemia, is included.
LC Classification Number
RC648-665.2
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