Biochemistry of Collagens, Laminins and Elastin : Structure, Function and Biomarkers by Morten Karsdal (2019, Trade Paperback)

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About this product

Product Identifiers

PublisherElsevier Science & Technology

ISBN-100128170689

ISBN-139780128170687

eBay Product ID (ePID)4038282162

Product Key Features

Number of PagesXliv, 389 Pages

Publication NameBiochemistry of Collagens, Laminins and Elastin : Structure, Function and Biomarkers

LanguageEnglish

SubjectLife Sciences / Biochemistry, Life Sciences / Biophysics

Publication Year2019

TypeTextbook

Subject AreaScience

AuthorMorten Karsdal

FormatTrade Paperback

Dimensions

Item Length9 in

Item Width6 in

Additional Product Features

Edition Number2

Intended AudienceScholarly & Professional

LCCN2019-944880

Dewey Edition23

IllustratedYes

Dewey Decimal572/.67

Table Of Content1. Type I collagen2. Type II collagen3. Type III collagen4. Type IV collagen5. Type V collagen6. Type VI collagen7. Type VII collagen8. Type VIII collagen9. Type IX collagen10. Type X collagen11. Type XI collagen12. Type XII collagen13. Type XIII collagen14. Type XIV collagen15. Type XV collagen16. Type XVI collagen17. Type XVII collagen18. Type XVIII collagen19. Type XIX collagen20. Type XX collagen21. Type XXI collagen22. Type XXII collagen23. Type XXIII collagen24. Type XXIV collagen25. Type XXV collagen26. Type XXVI collagen27. Type XXVII collagen28. Type XXVIII collagen29. Laminins30. Elastin31. The collagen chaperones32. Collagen diseases33. The signals of the extracellular matrix34. The roles of collagens in cancer35. Use of extracellular matrix biomarkers in clinical research36. Common confounders when evaluating noninvasive protein biomarkers37. Implementation of collagen biomarkers in the clinical setting

SynopsisThere are 28 different collagens, with 46 unique chains, which allows for a collagen for each time and place. Some collagens are specialized for basement membrane, whereas others are the central structural component of the interstitial matrix. There are eight collagens among the 20 most abundant proteins in the body, which makes these molecules essential building blocks of tissues. In addition, lessons learned from monogenomic mutations in these proteins result in grave pathologies, exemplifying their importance in development. These molecules, and their post-translationally modified products serve as biomarkers of diseases in a range of pathologies associated with the extracellular matrix. Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers, Second Edition provides researchers and students current data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of proteins can result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the extracellular matrix harbor cryptic signaling functions that may be viewed as endocrine function, and it highlights how this knowledge can be exploited to modulate fibrotic disease., There are 28 different collagens, with 46 unique chains, which allows for a collagen for each time and place. Some collagens are specialized for basement membrane, whereas others are the central structural component of the interstitial matrix. There are eight collagens among the 20 most abundant proteins in the body, which makes these molecules essential building blocks of tissues. In addition, lessons learned from monogenomic mutations in these proteins result in grave pathologies, exemplifying their importance in development. These molecules, and their post-translationally modified products serve as biomarkers of diseases in a range of pathologies associated with the extracellular matrix. Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers, Second Edition provides researchers and students current data on key structural proteins (collagens, laminins, and elastin), reviews on how these molecules affect pathologies, and information on how selected modifications of proteins can result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the extracellular matrix harbor cryptic signaling functions that may be viewed as endocrine function, and it highlights how this knowledge can be exploited to modulate fibrotic disease. Provides an updated comprehensive introduction to collagen and structural proteins Gives insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation Includes seven new chapters, including one on how collagen biomarkers are used in clinical research to support drug development and in precision medicine Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states Proves the importance of proteins for collagen assembly, function, and durability

LC Classification NumberQP552.C6B564 2019