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Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials,...

by Teicher, Beverly A. | HC | VeryGood
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US $8.11
Approximately£5.97
Condition:
Very Good
“May have limited writing in cover pages. Pages are unmarked. ~ ThriftBooks: Read More, Spend ”... Read moreAbout condition
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Item specifics

Condition
Very Good
A book that has been read and does not look new, but is in excellent condition. No obvious damage to the book cover, with the dust jacket (if applicable) included for hard covers. No missing or damaged pages, no creases or tears, no underlining or highlighting of text, and no writing in the margins. Some identifying marks on the inside cover, but this is minimal. Very little wear and tear. See the seller’s listing for full details and description of any imperfections. See all condition definitionsopens in a new window or tab
Seller notes
“May have limited writing in cover pages. Pages are unmarked. ~ ThriftBooks: Read More, Spend ...
Binding
Hardcover
Book Title
Anticancer Drug Development Guide
Weight
2 lbs
Product Group
Book
IsTextBook
Yes
ISBN
9781588292285

About this product

Product Identifiers

Publisher
Humana Press
ISBN-10
1588292282
ISBN-13
9781588292285
eBay Product ID (ePID)
6036695

Product Key Features

Number of Pages
Xiv, 451 Pages
Language
English
Publication Name
Anticancer Drug Development Guide : Preclinical Screening, Clinical Trials, and Approval
Subject
Oncology, Pharmacology
Publication Year
2004
Type
Textbook
Author
Paul A. Andrews
Subject Area
Medical
Series
Cancer Drug Discovery and Development Ser.
Format
Hardcover

Dimensions

Item Weight
79.7 Oz
Item Length
10 in
Item Width
7 in

Additional Product Features

Edition Number
2
Intended Audience
Scholarly & Professional
LCCN
2003-024925
Reviews
From Reviews of the First Edition: "...traces the critically important pathway by which a 'molecule' becomes an 'an anticancer agent'." -Unlisted Drugs "...this book is a must for all oncology fellows and junior faculty interested in drug development and will be a welcome addition on the bookshelf of all oncologists, pharmacists and other professionals interested in understanding this complex area." -Journal of Clinical Oncology, From Reviews of the First Edition:"...traces the critically important pathway by which a 'molecule' becomes an 'an anticancer agent'." -Unlisted Drugs"...this book is a must for all oncology fellows and junior faculty interested in drug development and will be a welcome addition on the bookshelf of all oncologists, pharmacists and other professionals interested in understanding this complex area." -Journal of Clinical Oncology
Dewey Edition
22
Number of Volumes
1 vol.
Illustrated
Yes
Dewey Decimal
616.99/4061
Table Of Content
I: In Vitro Methods.- 1 High-Volume Screening.- 2 High-Throughput Screening in Industry.- 3 The NCI Human Tumor Cell Line (60-Cell) Screen: Concept, Implementation, and Applications.- 4 Human Tumor Screening.- II: In Vivo Methods.- 5 Murine L1210 and P388 Leukemias.- 6 In Vivo Methods for Screening and Preclinical Testing: Use of Rodent Solid Tumors for Drug Discovery.- 7 Human Tumor Xenograft Models in NCI Drug Development.- 8 NCI Specialized Procedures in Preclinical Drug Evaluations.- 9 Patient-Like Orthotopic Metastatic Models of Human Cancer.- 10 Preclinical Models for Combination Therapy.- 11 Models for Biomarkers and Minimal Residual Tumor.- 12 Spontaneously Occurring Tumors in Companion Animals As Models for Drug Development.- III: Nonclinical Testing to Support Human Trials.- 13 Nonclinical Testing: From Theory to Practice.- 14 Nonclinical Testing for Oncology Drug Products.- 15 Nonclinical Testing for Oncology Biologic Products.- IV: Clinical Testing.- 16 Working With the National Cancer Institute.- 17 Phase I Trial Design and Methodology for Anticancer Drugs.- 18 Phase II Trials: Conventional Design and Novel Strategies in the Era of Targeted Therapies.- 19 Drug Development in Europe: The Academic Perspective.- 20 The Phase III Clinical Cancer Trial.- 21 Assessing Tumor-Related Symptoms and Health-Related Quality of Life in Cancer Clinical Trials: A Regulatory Perspective.- 22 The Role of the Oncology Drug Advisory Committee in the FDA Review Process for Oncologic Products.- 23 FDA Role in Cancer Drug Development and Requirements for Approval.
Synopsis
Focuses on both in vitro and in vivo screening methods; reviews how to work with the NCI, EORTC, and FDA requirements for approval; details successful strategies for working through phase I, II, and III clinical trials; in vivo methods include murine L1210 and P388 leukemias, high dose models, and human tumor xenografts; in vitro methods include high volume screening and human tumor screening., This unique volume traces the critically important pathway by which a "molecule" becomes an "anticancer agent. " The recognition following World War I that the administration of toxic chemicals such as nitrogen mustards in a controlled manner could shrink malignant tumor masses for relatively substantial periods of time gave great impetus to the search for molecules that would be lethal to specific cancer cells. Weare still actively engaged in that search today. The question is how to discover these "anticancer" molecules. Anticancer Drug Development Guide: Preclinical Screening, Clinical Trials, and Approval, Second Edition describes the evolution to the present of preclinical screening methods. The National Cancer Institute's high-throughput, in vitro disease-specific screen with 60 or more human tumor cell lines is used to search for molecules with novel mechanisms of action or activity against specific phenotypes. The Human Tumor Colony-Forming Assay (HTCA) uses fresh tumor biopsies as sources of cells that more nearly resemble the human disease. There is no doubt that the greatest successes of traditional chemotherapy have been in the leukemias and lymphomas. Since the earliest widely used in vivo drug screening models were the murine L 1210 and P388 leukemias, the community came to assume that these murine tumor models were appropriate to the discovery of "antileukemia" agents, but that other tumor models would be needed to discover drugs active against solid tumors.
LC Classification Number
RC254-282

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