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Cyclin-Depende
US $11.00
Approximately£8.24
Condition:
Like New
A book that has been read, but looks new. The book cover has no visible wear, and the dust jacket (if applicable) is included for hard covers. No missing or damaged pages, no creases or tears, no underlining or highlighting of text, and no writing in the margins. May have no identifying marks on the inside cover. No wear and tear. See the seller’s listing for full details and description of any imperfections.
- Buy it nowCyclin-Dependent Kinase (CDK) Inhibitors by P.K. Vogt & S.I. Reed HC
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Collection:
Free collection in person from Woburn, Massachusetts, United States
Postage:
US $4.40 (approx £3.30) USPS Media MailTM.
Located in: Woburn, Massachusetts, United States
Delivery:
Estimated between Sat, 2 Aug and Sat, 9 Aug to 94104
Returns:
30 days return. Buyer pays for return postage. If you use an eBay delivery label, it will be deducted from your refund amount.
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eBay item number:395250474583
Item specifics
- Condition
- ISBN
- 9783540634294
About this product
Product Identifiers
Publisher
Springer
ISBN-10
3540634290
ISBN-13
9783540634294
eBay Product ID (ePID)
415331
Product Key Features
Number of Pages
Xii, 169 Pages
Language
English
Publication Name
Cyclin-Dependent Kinase (Cdk) Inhibitors
Publication Year
1997
Subject
Life Sciences / Molecular Biology, Immunology, Life Sciences / Biochemistry, Oncology
Type
Textbook
Subject Area
Science, Medical
Series
Current Topics in Microbiology and Immunology Ser.
Format
Hardcover
Dimensions
Item Weight
14.8 Oz
Item Length
9.3 in
Item Width
6.1 in
Additional Product Features
Intended Audience
Scholarly & Professional
Series Volume Number
227
Number of Volumes
1 vol.
Illustrated
Yes
Synopsis
More than 10 years ago, the discovery of cyclin-dependent ki nases (Cdks) ushered in a new era in the understanding of cell proliferation and its control. Not only were both of the known cell cycle transitions, from G 1 to S phase and G2 to M phase, found to be dependent on these protein kinases, but the reg ulatory assumption intrinsic to cyclin-dependent kinases, a stable inactive catalytic subunit (the Cdk) and an unstable requisite positive regulatory activating subunit (the cyclin), led to a simple model for cell cycle control. Modulation of cyclin accumulation, and thereby Cdk activation, was proposed to be the overarching principle governing the passage through cell cycle phases. An other reality to emerge from the discovery of Cdks was the ex ceptional degree of evolutionary conservation maintained in the machinery and organization of proliferation control. Not only were Cdks shown to be structurally conserved between yeast and man, but mammalian Cdks could substitute functionally for the endogenous enzymes in a yeast cell. The problem of cell cycle control was thought to have been virtually solved. The ensuing years have provided a much more complex view of cell cycle control and the role and regulation of Cdks. The uncritical enthusiasm with which many of the ideas were em braced has required tempering. For example, although Cdks appear to be highly conserved phylogenetically, cyclins are much less so., More than 10 years ago, the discovery of cyclin-dependent ki nases (Cdks) ushered in a new era in the understanding of cell proliferation and its control. Not only were both of the known cell cycle transitions, from G 1 to S phase and G2 to M phase, found to be dependent on these protein kinases, but the reg ulatory assumption intrinsic to cyclin-dependent kinases, a stable inactive catalytic subunit (the Cdk) and an unstable requisite positive regulatory activating subunit (the cyclin), led to a simple model for cell cycle control. Modulation of cyclin accumulation, and thereby Cdk activation, was proposed to be the overarching principle governing the passage through cell cycle phases. An other reality to emerge from the discovery of Cdks was the ex ceptional degree of evolutionary conservation maintained in the machinery and organization of proliferation control. Not only were Cdks shown to be structurally conserved between yeast and man, but mammalian Cdks could substitute functionally for the endogenous enzymes in a yeast cell. The problem of cell cycle control was thought to have been virtually solved. The ensuing years have provided a much more complex view of cell cycle control and the role and regulation of Cdks. The uncritical enthusiasm with which many of the ideas were em braced has required tempering. For example, although Cdks appear to be highly conserved phylogenetically, cyclins are much less so."
LC Classification Number
QR180-189.5QH573-67
Item description from the seller
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- 2***0 (128)- Feedback left by buyer.Past 6 monthsVerified purchaseShipping was quick, packaging was excellent, condition was acceptable as described -- binding loose but pages intact. I did message buyer asking about mold and didn't receive a reply -- luckily, there appears to be no mold. Great value for a 100+ yr old book!
- a***p (8)- Feedback left by buyer.Past 6 monthsVerified purchaseI received my book in absolutely pristine condition, better than described! Which is impressive because the copy is from 1930 and it looks like it has never been handled. It shipped very quickly, even faster than the estimated time given by a week. It was packaged very carefully. The book and shipping price was also very fair considering the age and condition of the book and the shipping speed. I am very pleased with this seller and will be ordering from them again in the future.All Quiet on the Western Front by Erich Maria Remarque HC 1930 (#396258036329)
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