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The role of Indoleamine 2,3 Dioxygenase in Acute Myeloid Leukemia by Noura El Kholy, Haidy Habib (Paperback, 2012)

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Product Information

IDO has a role in immunosuppressive and tolerogenic mechanism in many solid tumor cells. Upregulation of IDO in acute myeloid leukemia has been recently reported. This book presents our research work which assessed both the IDO RNA expression & its enzymatic activity in the blast cells of AML patients. It also assessed the effect of pharmacological IDO inhibitor (1MT) on culture leukemia blast cells in relation to the effect of most traditionally used chemotherapeutic agent: adriamycin. The study included 25 AML patients & 25 healthy volunteers. All underwent assessment of IDO enzymatic activity & IDO RNA estimation by RT-PCR in peripheral blood MNCs. Also the MNCs were cultured to test the effect 1MT alone, and in combination with adriamycin on cell proliferation and IDO expression. The study revealed significant difference of IDO RNA expression & activity among the two groups (p > 0.01). Also there was a significant inhibition of proliferation of blast cells under the effect of both IDO inhibitor & adriamycin (p > 0.01). We concluded that, the role of IDO in tumor induced immune tolerance was confirmed and the benefits effect of IDO inhibitor in enhancing the anticancer effect

Product Identifiers

Publisher
LAP
ISBN-13
9783659000089
eBay Product ID (ePID)
138640241

Product Key Features

Author
Noura El Kholy, Haidy Habib
Publication Name
The Role of Indoleamine 23 Dioxygenase in Acute Myeloid Leukemia
Format
Paperback
Language
English
Subject
Chemistry
Publication Year
2012
Type
Textbook
Number of Pages
164 Pages

Dimensions

Item Height
229mm
Item Width
152mm
Item Weight
249g

Additional Product Features

Title_Author
Haidy Habib, Noura El Kholy
Country/Region of Manufacture
Germany

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The role of Indoleamine 2,3 Dioxygenase in Acute Myeloid Leukemia by Noura El Kholy, Haidy Habib (Paperback, 2012)

Best-selling in Adult Learning & University

Secrets Of Mental Math: The Mathemagician's Guide to Lightening Calculation and Amazing Maths Tricks by Arthur Benjamin, Michael Shermer (Paperback, 2006)

Never Split the Difference: Negotiating as if Your Life Depended on It by Chris Voss, Tahl Raz (Paperback, 2017)

Die with Zero: Getting All You Can from Your Money and Your Life by Bill Perkins (Paperback, 2021)

Adult Children of Emotionally Immature Parents: How to Heal from Distant, Rejecting, or Self-Involved Parents by Lindsay C Gibson (Paperback, 2015)

Code of Practice for In-service Inspection and Testing of Electrical Equipment by The Institution of Engineering and Technology (Paperback, 2020)

Clean & Green: 101 Hints and Tips for a More Eco-Friendly Home by Nancy Birtwhistle (Hardcover, 2021)

11+: Bond 11+ Assessment Papers Book 2 9-10 years bundle by Various (Paperback, 2021)

Save on Adult Learning & University

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The Concise Laws of Human Nature by Robert Greene Paperback, English

Zero to One: Notes on Start Ups, or How to Build the Future by Thiel, Peter The

Staring At The Sun: Being at peace with your own mortality by Irvin Yalom

Why We Get Sick (Paperback) by Bikman & Benjamin

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