CURRENTLY SOLD OUT
About this product
Product Identifiers
PublisherSpringer Berlin / Heidelberg
ISBN-103642099696
ISBN-139783642099694
eBay Product ID (ePID)108979574
Product Key Features
Number of PagesXiv, 254 Pages
Publication NameTransporters As Targets for Drugs
LanguageEnglish
SubjectLife Sciences / Human Anatomy & Physiology, Pharmacology, Chemistry / Organic
Publication Year2010
TypeTextbook
AuthorMatilda Bingham
Subject AreaScience, Medical
SeriesTopics in Medicinal Chemistry Ser.
FormatTrade Paperback
Dimensions
Item Weight16.2 Oz
Item Length9.3 in
Item Width6.1 in
Additional Product Features
Intended AudienceScholarly & Professional
Series Volume Number4
Number of Volumes1 vol.
IllustratedYes
Table Of ContentOverview: Transporters as Targets for Drug Discovery.- Membrane Transporters: Structure, Function and Targets for Drug Design.- Design of Monoamine Reuptake Inhibitors: SSRIs, SNRIs and NRIs.- Atypical Dopamine Uptake Inhibitors that Provide Clues About Cocaine's Mechanism at the Dopamine Transporter.- The Design, Synthesis and Structure-Activity Relationship of Mixed Serotonin, Norepinephrine and Dopamine Uptake Inhibitors.- Molecular Imaging of Transporters with Positron Emission Tomography.- Pharmacology of Glutamate Transport in the CNS: Substrates and Inhibitors of Excitatory Amino Acid Transporters (EAATs) and the Glutamate/Cystine Exchanger System x c '.- Glycine Transporters and Their Inhibitors.
SynopsisTransporters are proteins that span the plasma membrane and regulate the traf'c of small molecules in and out of the cell. They play a particularly important role in chemical signalling between neurons in the CNS, where they act to control the concentration of neurotransmitters in the synapse. In most systems the termination of chemical transmission is achieved by rapid uptake of the transmitter molecule from the synapse by transporters located on the synaptic terminal or surrounding glial cells. Another key role for transporters is in excluding undesirable xenobiotics from the cell, whilst allowing key molecules required for the cell life cycle to enter. It is incre- ingly recognised that these ef'ux or uptake transporters respectively, play an important role in the disposition of many marketed drugs, and whilst the ?eld of drug transport is yet to attain the level of maturity of drug metabolism, itiscertaintobeofincreasingimportance infuturedrugdisc- ery programmes. 2 Transporter Classification Transporters can be classed into two main families; the ATP binding c- sette (ABC) family, and the solute carrier (SLC) family. The SLC family is a very broad categorisation which encompasses, amongst others, three - portant families of transporters for organic molecules; the major facilitator superfamily (MFS) and two neurotransmitter transporter families, the neu- transmitter; sodium symporter (NSS, or SLC6) and the dicarboxylate/amino + + acid: cation (Na or H ) symporter (DAACS, or SLC1) family., Overview: Transporters as Targets for Drug Discovery.- Membrane Transporters: Structure, Function and Targets for Drug Design.- Design of Monoamine Reuptake Inhibitors: SSRIs, SNRIs and NRIs.- Atypical Dopamine Uptake Inhibitors that Provide Clues About Cocaine's Mechanism at the Dopamine Transporter.- The Design, Synthesis and Structure-Activity Relationship of Mixed Serotonin, Norepinephrine and Dopamine Uptake Inhibitors.- Molecular Imaging of Transporters with Positron Emission Tomography.- Pharmacology of Glutamate Transport in the CNS: Substrates and Inhibitors of Excitatory Amino Acid Transporters (EAATs) and the Glutamate/Cystine Exchanger System x c ?.- Glycine Transporters and Their Inhibitors., Transporters are proteins that span the plasma membrane and regulate the traf'c of small molecules in and out of the cell. They play a particularly important role in chemical signalling between neurons in the CNS, where they act to control the concentration of neurotransmitters in the synapse. In most systems the termination of chemical transmission is achieved by rapid uptake of the transmitter molecule from the synapse by transporters located on the synaptic terminal or surrounding glial cells. Another key role for transporters is in excluding undesirable xenobiotics from the cell, whilst allowing key molecules required for the cell life cycle to enter. It is incre- ingly recognised that these ef'ux or uptake transporters respectively, play an important role in the disposition of many marketed drugs, and whilst the ?eld of drug transport is yet to attain the level of maturity of drug metabolism,itiscertaintobeofincreasingimportance infuturedrugdisc- ery programmes. 2 Transporter Classification Transporters can be classed into two main families; the ATP binding c- sette (ABC) family, and the solute carrier (SLC) family. The SLC family is a very broad categorisation which encompasses, amongst others, three - portant families of transporters for organic molecules; the major facilitator superfamily (MFS) and two neurotransmitter transporter families, the neu- transmitter; sodium symporter (NSS, or SLC6) and the dicarboxylate/amino + + acid:cation (Na or H ) symporter (DAACS, or SLC1) family.
LC Classification NumberQP34-38
