I have been taking SAMe for 6 years with great health benefits for my disability. These ones turned up in loose sleeves and packaging separate . They tasted sour and did not work . I have been told to return them but have already binned them as are unsafe . Therefore I can’t get refund . There advise was to to contact Dr Best as that’s where the supplier got them from . However it’s not Dr Best fault as been using same product from different supplier for years . Unfortunately my usual supplier wasn’t available . Lesson learned :((((. loss of £29.99 isn’t great for me as i’m on disability pension and now have to find more money for tablets i totally rely on !!