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Design & Evaluation of Orally Disintegrating Tablet of Antiemetic Drug: Oral Dis - Picture 1 of 1

Design & Evaluation of Orally Disintegrating Tablet of Antiemetic Drug by Kunal Patel, Poraskumar Patel, Bhavanaben Patel (Paperback, 2012)

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ODTs were produced by directly compressing a mixture containing superdisintegrant, diluent, glidant, lubricant, and sweetener.

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The bitter taste of the drug was masked by Kyron T 114, a weak cation exchange resins with the method of ion exchange resin complexation, Which was prepared by the batch technique and various parameters (i.e. resin ratio, pH, Temperature, swelling time and stirring time) was optimized to successfully formulate the resinate into ODT and it was confirmed by FTIR and DSC study. ODTs were produced by directly compressing a mixture containing superdisintegrant, diluent, glidant, lubricant, and sweetener. In preliminary trials selection of superdisintegrants (i.e., crosspovidone XL 10, cross carmellose sodium and sodium starch glycolate) and Selection of diluent (i.e. mannitol SD 200, Avicel pH 102 Avicel pH 112, Starch and pregelatinized starch) were made. The cohesive force of mannitol increase wetting time and Disintegration time so drug release was delayed. 32 factorial design was applied in which superdisintegrant and diluent ratio were taken as independent factor and disintegration time and wetting time were taken as response.