Reviews"This book is both impressive and remarkable. ... Dr. Mueller has indeed articulated legitimate questions and hypotheses. ... The persistence of these attitudes makes this book as remarkable apropos the publisher as it is impressive apropos the author. Accordingly, the academic publishing giant Springer Nature, surely understood that because COVID-19 will be studied and debated for decades, it is essential that a sourcebook ... should exist in the mainstream academic literature. ... Dr. Mueller's work takes on greater significance." (David Wiseman, ResearchGate, researchgate.net, May 23, 2024)
Dewey Edition23
Table Of ContentChapter 1: Introduction.- Part I: Scientifi Underpinnings, early expectations, and emerging challenges from the global inoculation experience.- Chapter 2: Appraisal of Some of the Key Postulates Underlying mRNA Vaccines.- Chapter 3: Relevance for mRNA vaccine safety.- Chapter 4: From Challenges to Opportunities and Open Questions.- Chapter 5: The challenge of evaluating vaccine safety and effectiveness.- Chapter 6: Safeguarding against the analog of antimicrobial-resistance development.- Chapter 7: Scales, pseudoscales, the human factor, and a way forward.- Part II: A deeper dive into mRNA vaccine safety and security, and developments until Delta.- Chapter 8: mRNA Vaccine safety and efficacy - official criteria when AEs are caused by the injection.- Chapter 9: mRNA Covid-19 vaccines best reflect effective pharmaceuticals - basic considerations and LNPs.- Chapter 10: mRNA Covid-19 pharmaceuticals and the spike antigen.- Chapter 11: Other facets of SARS-CoV-2 immunity, the risk of immune tolerance and T cell exhaustion.- Part III: The Omicron variants.- Chapter 12: Omicron.- Chapter 13: Conclusion.
SynopsisThis book offers an analytical look at the much debated risks and benefits of the newly developed COVID-19 mRNA-vaccines. As such, it is one of the first books to give a comprehensive overview of mRNA vaccines against COVID-19 and the only one that addresses this topic from a broad multidisciplinary background. It brings together insights from various underlying disciplines on the challenges of developing and evaluating the most suitable vaccines for mass vaccination programs enrolled throughout the world - focusing on safety and efficacy. This book should not be missing on the shelf of any biomedical researcher, epidemiologist, public health professional or clinical researcher interested in SARS-CoV2 or virology and vaccine development in general.