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About this product
Product Identifiers
PublisherSpringer Berlin / Heidelberg
ISBN-103642411983
ISBN-139783642411984
eBay Product ID (ePID)170340080
Product Key Features
Number of PagesVIII, 447 Pages
Publication NameArrestins-Pharmacology and Therapeutic Potential
LanguageEnglish
Publication Year2013
SubjectLife Sciences / Biochemistry, Pharmacology, Life Sciences / Biology, Chemistry / Organic
TypeTextbook
AuthorVsevolod V. Gurevich
Subject AreaScience, Medical
SeriesHandbook of Experimental Pharmacology Ser.
FormatHardcover
Dimensions
Item Weight312.8 Oz
Item Length9.3 in
Item Width6.1 in
Additional Product Features
Intended AudienceScholarly & Professional
LCCN2013-955574
Dewey Edition23
Series Volume Number219
Number of Volumes1 vol.
IllustratedYes
Dewey Decimal572.696
Table Of ContentTherapeutic Potential of Small Molecules and Engineered Proteins.-Arrestin Interactions with G Protein-coupled Receptors.- Arrestin-biased GPCR Agonists.- Arrestin-1 Expression Levels, Rod Function and Health.- Protective Functions of Arrestin-1 in Photoreceptors.- Arrestin-4 and Cone Function.- Enhanced Phosphorylation-independent Arrestins and Gene Therapy.- Targeting Particular Receptors with Redesigned Non-visual Arrestins.- Arrestins binding to clathrin, AP2 and Role in GPCR trafficking.- Arrestins in Ubiquitination and Deubiquitination.- Arrestin Self-association.- Arrestin-dependent Activation of ERK and Src.- Arrestin-dependent Activation of JNK Family Kinases.- Arrestin-Mediated P38 Activation.- Arrestin-dependent PDE Localization.- Arrestins in Cell Migration.- Arrestins in Host-pathogen Interactions.- Arrestin Regulation of Small GTPases.- GPCRs and Arrestins in Airways: Implications for Asthma.- Arrestins as Regulatory Signaling Hubs in Cancer Pathways.- Arrestins in Pain and Anesthesia.
SynopsisThis volume in Springer's authoritative series on experimental pharmacology covers the molecular mechanisms and therapeutic implications of arrestin-mediated signaling, including the potential of re-engineered signaling proteins in the field of gene therapy., This volume describes our current understanding of the biological role of visual and non-visual arrestins in different cells and tissues, focusing on the mechanisms of arrestin-mediated regulation of GPCRs and non-receptor signaling proteins in health and disease. The book covers wide range of arrestin functions, emphasizing therapeutic potential of targeting arrestin interactions with individual partners.
LC Classification NumberRM300-666
