We have 2 chihuahuas in our family that have extremely sensitive stomachs. One has actually been hospitalized for colitis. Both can only eat EN prescription diet, and both eat these as treats. We've had no problems with either. I do break them into fourths since they are too large for a toy breed. I am so grateful that now, these little girls can have treats like the other dogs in the family
My poodles cannot eat most dog treats, most of them are not very nutritional and are harsh on their sensitive tummies. They love to get rewarded with Purina Gentle snackers, I've been using them for years, and they have never caused any stomach upsets.