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Human Longevity : Omega-3 Fatty Acids, Bioenergetics, Molecular Biology, and Evolution by Raymond C. Valentine and David L. Valentine (2014, Hardcover)
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HUMAN LONGEVITY: OMEGA-3 FATTY ACIDS, BIOENERGETICS, MOLECULAR BIOLOGY, AND EVOLUTION By Raymond C. Valentine & David L. Valentine - Hardcover **BRAND NEW**.
- Buy it nowHUMAN LONGEVITY: OMEGA-3 FATTY ACIDS, BIOENERGETICS, By Raymond C. Valentine
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About this product
Product Identifiers
PublisherCRC Press LLC
ISBN-101466594861
ISBN-139781466594869
eBay Product ID (ePID)201633009
Product Key Features
Number of Pages259 Pages
Publication NameHuman Longevity : Omega-3 Fatty Acids, Bioenergetics, Molecular Biology, and Evolution
LanguageEnglish
Publication Year2014
SubjectLife Sciences / Microbiology, Life Sciences / Molecular Biology, Endocrinology & Metabolism, Genetics, Physiology, Biochemistry, Chemistry / General
TypeTextbook
AuthorRaymond C. Valentine, David L. Valentine
Subject AreaScience, Medical
FormatHardcover
Dimensions
Item Height1 in
Item Weight17.6 Oz
Item Length9.5 in
Item Width6.2 in
Additional Product Features
Intended AudienceCollege Audience
LCCN2014-010535
Dewey Edition23
IllustratedYes
Dewey Decimal612.67
Table Of ContentINTRODUCTION TO THE SCIENCE OF HUMAN AGING Mitochondrial Hypothesis of Aging Is Undergoing Revision Oxidative Stress Defined as a Deadly Free Radical-Mediated Chain Reaction: Case History of Paraquat Membranes of Deep-Sea Bacteria as Surrogates for Mitochondrial Membranes of Humans DARWINIAN SELECTION OF MEMBRANES ENABLING LONGEVITY Protective Mechanisms for EPA Membranes in C. elegans and Their Relationship to Life Span Remarkable Longevity of Queens of Social Insects Likely Involves Dietary Manipulation to Minimize Levels of Polyunsaturates and Decrease Membrane Peroxidation Membrane Peroxidation Hypothesis Helps Explain Longevity in Birds, Rodents, and Whales Did Longevity Help Humans Become Super Humans? REVISED MITOCHONDRIAL MEMBRANE HYPOTHESIS OF AGING Mitochondrial Diseases and Aging Have Much in Common Revised Mitochondrial Hypothesis of Aging Highlights Energy Deficiency Caused by Errors of Replication (Mutations) of mtDNA Benefits of Polyunsaturated Mitochondrial Membranes Mitochondrial Membranes as a Source of Reactive Oxygen Species (ROS) Mitochondrial Membranes as Major Targets of Oxidation MANY MECHANISMS HAVE EVOLVED TO PROTECT HUMAN MITOCHONDRIAL MEMBRANES, ENABLING LONGEVITY Apoptosis Caused by Oxidatively Truncated Phospholipids Can Be Reversed by Several Mechanisms, Especially Enzymatic Detoxification Selective Targeting of HUFAs Away from Cardiolipin and Beta-Oxidation Combine to Protect Mitochondrial Membranes Against Oxidative Damage Oxygen Limitation Protects Mitochondrial Phospholipids, Especially Cardiolipin Uncoupling Proteins (UCPs) of Mitochondria Purposely Waste Energy to Prevent Membrane Damage Mitochondrial Fission Protects against Oxidative Stress by Minting a Continuous Supply of Cardiolipin and Other Polyunsaturated Phospholipids Mitophagy Eliminates Toxic Mitochondria Longevity Genes Likely Protect Membranes Aging as a Cardiolipin Disease That Can Be Treated Index
SynopsisMore than 7 billion people inhabit the earth and all of them are subject to aging. This book is aimed at persons interested in a molecular explanation of how our cells age. Human Longevity: Omega-3 Fatty Acids, Bioenergetics, Molecular Biology, and Evolution is built on the proposition that we age as our mitochondria age. It suggests a revised version of Harman's famous hypothesis featuring mitochondrial oxidative and energy stresses as the root causes of aging. Human cells are protected from the ravages of aging by a battery of defensive systems including some novel mechanisms against membrane oxidation introduced in this book. This concept is consistent with recent discoveries showing that mitochondria-targeted antioxidants prevent Huntington's disease, Parkinson's disease, and traumatic brain disease in animal models of neurodegeneration. This book explores a unified theory of aging based on bioenergetics. It covers a variety of topics including an introduction to the science of human aging, the Darwinian selection of membranes enabling longevity, a revised mitochondrial membrane hypothesis of aging, and various mechanisms that protect human mitochondrial membranes, thereby enabling longevity.
LC Classification NumberQP86.V35 2014
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