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Orphan: the Quest to Save Children with Rare Genetic Disorders by Philip R. Reilly (2015, Hardcover)
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ORPHAN: THE QUEST TO SAVE CHILDREN WITH RARE GENETIC DISORDERS By Philip R. Reilly - Hardcover **BRAND NEW**.
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About this product
Product Identifiers
PublisherCold Spring Harbor Laboratory Press
ISBN-101621821374
ISBN-139781621821373
eBay Product ID (ePID)211324414
Product Key Features
Number of Pages408 Pages
Publication NameOrphan: the Quest to Save Children with Rare Genetic Disorders
LanguageEnglish
Publication Year2015
SubjectPediatrics, Life Sciences / Genetics & Genomics, Genetics, Diseases
TypeTextbook
Subject AreaScience, Medical
AuthorPhilip R. Reilly
FormatHardcover
Dimensions
Item Height1.4 in
Item Weight28.1 Oz
Item Length6.3 in
Item Width9.2 in
Additional Product Features
Intended AudienceTrade
LCCN2015-009762
ReviewsA physician, attorney, and biotech entrepreneur, Philip Reilly clearly illuminates rare genetic disorders, the struggle to understand and treat them, and the promise of the latest advances in genetic testing and therapy. Engaging and compassionate, Orphan brings the exciting advances in biomedical research to life. This excellent volume is enriched by the often heroic stories of parents and physician-scientists determined to find answers. - David J. Skorton, MD, Secretary, The Smithsonian Institution A fascinating, engaging, and at times inspiring look at the past, present, and future of genetic medicine told through the stories of scientists, doctors, patients, and parents who were heroes in the fight against genetic disease. Thoroughly enjoyable. - Hank Greely, Stanford Law School, an authority on public policy issues in genetics Reilly's Orphan provides a very interesting and readable history of the various approaches used in efforts to first understand and then treat children who suffer from rare genetic diseases. Research efforts to identify rare genetic changes that cause disease used to require decades and large families, but with the rapid advances in genome sequencing over the past 15 years, this can now be done in weeks. Orphan discusses how these new discoveries might be coupled with gene editing or cell therapy to offer new hope to families. - J. Craig Venter, PhD, Chairman and CEO, J. Craig Venter Institute, and a pioneer in human genomics Written with clarity and from first hand experience by a pioneer who is helping to develop new breakthrough therapies for children with rare genetic diseases, this book takes you by the hand and pulls you into the world of these children and their heroic parents, many of whom helped to champion new treatments working with equally heroic scientists and physicians. The story is truly compelling. - Donald Ingber, MD,PhD, Founding Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University, "A physician, attorney, and biotech entrepreneur, Philip Reilly clearly illuminates rare genetic disorders, the struggle to understand and treat them, and the promise of the latest advances in genetic testing and therapy. Engaging and compassionate, Orphan brings the exciting advances in biomedical research to life. This excellent volume is enriched by the often heroic stories of parents and physician-scientists determined to find answers." - David J. Skorton, MD, Secretary, The Smithsonian Institution "A fascinating, engaging, and at times inspiring look at the past, present, and future of genetic medicine told through the stories of scientists, doctors, patients, and parents who were heroes in the fight against genetic disease. Thoroughly enjoyable." - Hank Greely, Stanford Law School, an authority on public policy issues in genetics "Reilly's Orphan provides a very interesting and readable history of the various approaches used in efforts to first understand and then treat children who suffer from rare genetic diseases. Research efforts to identify rare genetic changes that cause disease used to require decades and large families, but with the rapid advances in genome sequencing over the past 15 years, this can now be done in weeks. Orphan discusses how these new discoveries might be coupled with gene editing or cell therapy to offer new hope to families." - J. Craig Venter, PhD, Chairman and CEO, J. Craig Venter Institute, and a pioneer in human genomics "Written with clarity and from first hand experience by a pioneer who is helping to develop new breakthrough therapies for children with rare genetic diseases, this book takes you by the hand and pulls you into the world of these children and their heroic parents, many of whom helped to champion new treatments working with equally heroic scientists and physicians. The story is truly compelling." - Donald Ingber, MD, PhD, Founding Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University, "A physician, attorney, and biotech entrepreneur, Philip Reilly clearly illuminates rare genetic disorders, the struggle to understand and treat them, and the promise of the latest advances in genetic testing and therapy. Engaging and compassionate, Orphan brings the exciting advances in biomedical research to life. This excellent volume is enriched by the often heroic stories of parents and physician-scientists determined to find answers." - David J. Skorton, MD, Secretary, The Smithsonian Institution "A fascinating, engaging, and at times inspiring look at the past, present, and future of genetic medicine told through the stories of scientists, doctors, patients, and parents who were heroes in the fight against genetic disease. Thoroughly enjoyable." - Hank Greely, Stanford Law School, an authority on public policy issues in genetics"Reilly's Orphan provides a very interesting and readable history of the various approaches used in efforts to first understand and then treat children who suffer from rare genetic diseases. Research efforts to identify rare genetic changes that cause disease used to require decades and large families, but with the rapid advances in genome sequencing over the past 15 years, this can now be done in weeks. Orphan discusses how these new discoveries might be coupled with gene editing or cell therapy to offer new hope to families." - J. Craig Venter, PhD, Chairman and CEO, J. Craig Venter Institute, and a pioneer in human genomics"Written with clarity and from first hand experience by a pioneer who is helping to develop new breakthrough therapies for children with rare genetic diseases, this book takes you by the hand and pulls you into the world of these children and their heroic parents, many of whom helped to champion new treatments working with equally heroic scientists and physicians. The story is truly compelling." - Donald Ingber, MD, PhD, Founding Director of the Wyss Institute for Biologically Inspired Engineering at Harvard University
Dewey Edition23
IllustratedYes
Dewey Decimal618.92/0042
Table Of ContentPreface, ix Acknowledgments Introduction 1. Diet 2. The Rise of Medical Genetics 3. Blood 4. Genetic Testing: Avoiding Disease 5. Stem Cells: Creating Human Mosaics 6. Enzyme Replacement Therapy: Genetically Engineered Drugs 7. Gene Therapy: Using Viruses to Deliver Normal Genes 8. Overcoming Mutations 9. Butterfly Children: Rebuilding the Skin 10. Ligands: Turning Genes On 11. Mending Broken Proteins 12. What Is Next: Emerging Therapies 13. We Are All Orphans: Lessons for Common Diseases Bibliography Index
SynopsisOrphan is more than a book about disease and research--it gives voice to thousands of people who, all too often, have endured terrible illnesses, bravely faced arduous clinical trials, and, sometimes, have gained victories, almost always in silence. This book recounts extraordinary breakthroughs and hopes for the future. Many of the disorders that will end our lives are in some part genetically influenced. We really are all orphans, and this book is for all of us., Orphan is about the struggle to save the lives of children who, because of an unlucky roll of the genetic dice, are born with any one of several thousand rare genetic disorders. Many are burdened with diseases that carry mysterious names, some of which you can read about for the first time in this book, along with compelling stories about the physicians, scientists, and parents who have taken them on. The diseases include phenylketonuria, sickle cell anemia, dystrophic epidermolysis bullosa, X-linked hypohidrotic ectodermal dysplasia, and Friedreich's ataxia-just a few of the more than 1000 genetic disorders that are well-described and many more that are not. Many manifest in infancy. Some show up in mid-childhood, others later in childhood, and still others among adults. They touch almost every extended family. Orphan is more than a book about disease and research--it gives voice to thousands of people who, all too often, have endured terrible illnesses, bravely faced arduous clinical trials, and, sometimes, have gained victories, almost always in silence. This book recounts extraordinary breakthroughs and hopes for the future. Many of the disorders that will end our lives are in some part genetically influenced. We really are all orphans, and this book is for all of us.
LC Classification NumberRJ47.3.R45 2015
