Table Of ContentMicro- and Nano-Technologies to Probe Brain Mechanobiology.- Acute Neural Stimulation.- Chronic Neural Stimulation.- Phenotypic Selection of Magnetospirillum magneticum (AMB-1) Over-Producers using Magnetic Ratcheting.- Magnetic Microfluidic Separation for Estimating the Magnetic Contents of Magnetotactic Bacteria.- Outlook for Magnetic Neural Stimulation Techniques.
SynopsisThis book describes the tools, developed by the author, for perturbing endogenous mechano-sensitive ion channels for magneto-mechanical neuro-modulation. He explores the ways in which these tools compare against existing ones such as electricity, chemicals, optogenetics, and techniques like thermos/magneto-genetics. The author also reports on two platforms--magnetic ratcheting and magnetic microfluidics for directed evolution and high throughput culture of magnetotactic bacteria--that produce high quality magnetic nanoparticles for biomedical applications like neural stimulations. This thesis was submitted to and approved by the University of California, Los Angeles., Introduces technology for non-invasive control of neural activities that offer deep tissue penetration and controllable dosage; Examines the effects of biomechanical forces on cellular functions; Explores how to improve the reproducibility and uptake of magnetic tools for non-invasive neural modulation.