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Theoretical and Computational Chemistry Ser.: Cheminformatics and Bioinformatics at the Interface with Systems Biology : Bridging Chemistry and Medicine by Aman Chandra Kaushik, Sadia Nawab, Dongqing Wei, Aamir Mehmood and Shakti Sahi (2023, Hardcover)

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About this product

Product Identifiers

PublisherRoyal Society of Real Chemistry, T.H.E.

ISBN-101839161620

ISBN-139781839161629

eBay Product ID (ePID)27057271784

Product Key Features

Number of Pages280 Pages

Publication NameCheminformatics and Bioinformatics at the Interface with Systems Biology : Bridging Chemistry and Medicine

LanguageEnglish

Publication Year2023

SubjectChemistry / Clinical, Chemistry / Physical & Theoretical, Chemistry / Computational & Molecular Modeling

TypeTextbook

Subject AreaScience

AuthorAman Chandra Kaushik, Sadia Nawab, Dongqing Wei, Aamir Mehmood, Shakti Sahi

SeriesTheoretical and Computational Chemistry Ser.

FormatHardcover

Dimensions

Item Weight44.4 Oz

Item Length9.2 in

Item Width6.2 in

Additional Product Features

Intended AudienceScholarly & Professional

LCCN2022-303260

Dewey Edition23

Series Volume NumberVolume 24

Dewey Decimal615.1900285

Table Of ContentSystem Biology and Drug Target Identification;Modulating Drug Target Gene Expression in Cancer;Drug Repositioning Using Genome-wide Screening and Systems Biology Approaches and Applications;New Directions in System Biology-based Target Identification and Cancer Genome Analysis;Molecular Investigation of Protein-Protein Interaction Candidates Related to Mammalian Brain;Biological Systems to Computational Systems Biology;Controlled Vocabularies and Semantics in Systems Biology;Single-molecule Imaging in Biosystems;Tracking the Emergence of Synthetic Biology;Synthetic Biology: Fostering the Cyber-biological Revolution;Computational Systems Chemical Biology;Systems Biology Methods to Assist in the Discovery of Efficacious Drug Combinations

SynopsisAddressing the fundamental aspects of the various computational tools for drug discovery, this book compiles recent bioinformatics and chemoinformatics approaches, and their integration with systems biology., The cost of drug development is increasing, and investment returns are decreasing. The number of drugs approved by FDA is in decline in terms of the number of new molecular entities (NMEs). Amongst the reasons noted for this are the adverse side effects and reduced efficiency of many of the potential compounds. This is a problem both for the pharmaceutical industry and for those suffering from diseases for which there are no or few available treatments. Advances in computational chemistry, computer science, structural biology and molecular biology have all contributed to improved drug design strategies and reduced the time taken for drug discovery. By interfacing cheminformatics and bioinformatics with systems biology we can create a powerful tool for understanding the mechanisms of patho-physiological systems and identifying lead molecules for various diseases. This integration of drug design approaches can also play a crucial role in the prediction and rationalization of drug effects and side effects, improving safety and efficacy and leading to better approval rates. Addressing the lack of knowledge on the fundamental aspects of the various computational tools for drug discovery, this book is a compilation of recent bioinformatics and cheminformatics approaches, and their integration with systems biology. Written primarily for researchers and academics in chem- and bioinformatics, it may also be a useful resource for advanced-level students.

LC Classification NumberRS420