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Inflamed Mind : A Radical New Approach to Depression by Edward Bullmore (2018, Hardcover)

Bokonon Books (190)

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About this product

Product Identifiers

PublisherPicador

ISBN-101250318149

ISBN-139781250318145

eBay Product ID (ePID)8038457946

Product Key Features

Book TitleInflamed Mind : a Radical New Approach to Depression

Number of Pages256 Pages

LanguageEnglish

TopicLife Sciences / Neuroscience, Psychopathology / Depression, General, Clinical Psychology

Publication Year2018

IllustratorYes

GenreBody, Mind & Spirit, Science, Psychology

AuthorEdward Bullmore

FormatHardcover

Dimensions

Item Height0.9 in

Item Weight14.4 Oz

Item Length9.6 in

Item Width6.5 in

Additional Product Features

Intended AudienceTrade

LCCN2018-030320

Reviews"A rousing, straight-from-the shoulder call for a new approach to treating depression...Impressive and valuable... aimed at the general public, [ The Inflamed Mind is] highly readable, and more than a little provocative." -- Kirkus Reviews "[A] targeted, readable primer... [and] a well-informed and cogently argued brief for funding and more investigation in the field." -- Publishers Weekly " The Inflamed Mind is not only a dramatic breakthrough in our understanding of depression. It is an extraordinary exploration of what it is to be human." -- Matthew d'Ancona, author of Post Truth " The Inflamed Mind confronts the reader with the converging revolutions in neuroscience and immunology that give rise to a new perspective about depression and its treatment. It traces the roots of dualism,the tendency to view mind dissociated from body, and then calls for moving beyond dualism in order to understand how inflammation in the body affects brain and mind. In an erudite, enjoyable, and accessible way, Professor Bullmore conveys the profound impact of this new perspective by helping us to appreciate the links between traditional 'medical' and 'psychiatric' syndromes and it identifies new anti-inflammatory treatments that may cross the boundary from general medicine to psychiatry." --John H. Krystal, M.D., Robert L. McNeil, Jr., professor of translational research; chair, department of psychiatry, Yale University School of Medicine "Ed Bullmore provides a clearly written and compelling argument for the importance of the immune system and inflammation in depression. This lively book explains a major frontier in clinical neuroscience that is not only influencing research on depression, but also on schizophrenia and Alzheimer's disease." --Steven E. Hyman, Harvard University "Here is a narrative that tells of exciting new approaches to reducing mental illness while capturing the essence of a powerful strand in fundamental brain science. Even better: it is easy to read without overly simplifying its subject." -- Sir Philip Campbell, Editor-in-Chief, Nature "An important book, a hopeful book, for anyone who wants to think about depression in a new way." --Tom Insel, MD, cofounder and president of Mindstrong Health "As one of the first people to brand themselves as animmunopsychiatrist, Professor Bullmore has led us out of the dark ages and shone the light on the crucial link between systemic inflammation and mental illness. This set of insights is creating a paradigm shift in psychiatry which heralds a new field of personalized psychiatry in the same way that we are seeing personalized therapy in chancer." --Sir Robert Lechler, president of the Academy of Medical Sciences "A compelling and highly readable argument that some forms of mental illness are really diseases of the immune system. If Bullmore is right, psychiatry is on the brink of a revolution--the reunion of body and mind." -- Sir Colin Blakemore, Professor of Neuroscience & Philosophy, School of Advanced Study, University of London "Suddenly an expert who wants to stop and question everything we thought we knew...This is a lesson in the workings of the brain far too important to ignore." --Jeremy Vine, BBC, "A rousing, straight-from-the shoulder call for a new approach to treating depression...Impressive and valuable... aimed at the general public, [The Inflamed Mind is] highly readable, and more than a little provocative." -- Kirkus Reviews "[A] targeted, readable primer... [and] a well-informed and cogently argued brief for funding and more investigation in the field." -- Publishers Weekly "Ed Bullmore provides a clearly written and compelling argument for the importance of the immune system and inflammation in depression. This lively book explains a major frontier in clinical neuroscience that is not only influencing research on depression, but also on schizophrenia and Alzheimer's disease." --Steven E. Hyman, Harvard University "An important book, a hopeful book, for anyone who wants to think about depression in a new way." --Tom Insel, MD, cofounder and president of Mindstrong Health " The Inflamed Mind confronts the reader with the converging revolutions in neuroscience and immunology that give rise to a new perspective about depression and its treatment. It traces the roots of dualism,the tendency to view mind dissociated from body, and then calls for moving beyond dualism in order to understand how inflammation in the body affects brain and mind. In an erudite, enjoyable, and accessible way, Professor Bullmore conveys the profound impact of this new perspective by helping us to appreciate the links between traditional 'medical' and 'psychiatric' syndromes and it identifies new anti-inflammatory treatments that may cross the boundary from general medicine to psychiatry." --John H. Krystal, M.D., Robert L. McNeil, Jr., professor of translational research; chair, department of psychiatry, Yale University School of Medicine "As one of the first people to brand themselves as animmunopsychiatrist, Professor Bullmore has led us out of the dark ages and shone the light on the crucial link between systemic inflammation and mental illness. This set of insights is creating a paradigm shift in psychiatry which heralds a new field of personalized psychiatry in the same way that we are seeing personalized therapy in chancer." --Sir Robert Lechler, president of the Medical Sciences "Suddenly an expert who wants to stop and question everything we thought we knew...This is a lesson in the workings of the brain far too important to ignore." --Jeremy Vine, BBC, "Ed Bullmore provides a clearly written and compelling argument for the importance of the immune system and inflammation in depression. This lively book explains a major frontier in clinical neuroscience that is not only influencing research on depression, but also on schizophrenia and Alzheimer's disease." --Steven E. Hyman, Harvard University "An important book, a hopeful book, for anyone whowants to think about depression in a new way." --Tom Insel, MD, cofounder and president of Mindstrong Health " The Inflamed Mind confronts the reader with theconverging revolutions in neuroscience and immunology that give rise to a newperspective about depression and its treatment. It traces the roots of dualism,the tendency to view mind dissociated from body, and then calls for movingbeyond dualism in order to understand how inflammation in the body affectsbrain and mind. In an erudite, enjoyable, and accessible way, Professor Bullmore conveys the profound impact of this new perspective by helping us toappreciate the links between traditional 'medical' and 'psychiatric' syndromesand it identifies new anti-inflammatory treatments that may cross the boundaryfrom general medicine to psychiatry." --John H. Krystal, M.D., Robert L. McNeil,Jr., Professor of Translational Research; Chair, Department of Psychiatry, Yale University School of Medicine "As one of the first people to brand themselves as animmunopsychiatrist, Professor Bullmore has led us out of the dark ages andshone the light on the crucial link between systemic inflammation and mentalillness. This set of insights is creating a paradigm shift in psychiatry whichheralds a new field of personalized psychiatry in the same way that we are seeingpersonalized therapy in chancer." --Sir Robert Lechler, President of the Medical Sciences "Suddenly an expert who wants to stop and questioneverything we thought we knew...This is a lesson in the workings of the brain fartoo important to ignore." --Jeremy Vine, "[A] targeted, readable primer... [and] a well-informed and cogently argued brief for funding and more investigation in the field." --Publishers Weekly "Ed Bullmore provides a clearly written and compelling argument for the importance of the immune system and inflammation in depression. This lively book explains a major frontier in clinical neuroscience that is not only influencing research on depression, but also on schizophrenia and Alzheimer's disease." --Steven E. Hyman, Harvard University "An important book, a hopeful book, for anyone whowants to think about depression in a new way." --Tom Insel, MD, cofounder and president of Mindstrong Health " The Inflamed Mind confronts the reader with theconverging revolutions in neuroscience and immunology that give rise to a newperspective about depression and its treatment. It traces the roots of dualism,the tendency to view mind dissociated from body, and then calls for movingbeyond dualism in order to understand how inflammation in the body affectsbrain and mind. In an erudite, enjoyable, and accessible way, Professor Bullmore conveys the profound impact of this new perspective by helping us toappreciate the links between traditional 'medical' and 'psychiatric' syndromesand it identifies new anti-inflammatory treatments that may cross the boundaryfrom general medicine to psychiatry." --John H. Krystal, M.D., Robert L. McNeil, Jr., professor of translational research; chair, department of psychiatry, Yale University School of Medicine "As one of the first people to brand themselves as animmunopsychiatrist, Professor Bullmore has led us out of the dark ages andshone the light on the crucial link between systemic inflammation and mentalillness. This set of insights is creating a paradigm shift in psychiatry whichheralds a new field of personalized psychiatry in the same way that we are seeingpersonalized therapy in chancer." --Sir Robert Lechler, president of the Medical Sciences "Suddenly an expert who wants to stop and questioneverything we thought we knew...This is a lesson in the workings of the brain far too important to ignore." --Jeremy Vine, BBC, "A rousing, straight-from-the shoulder call for a new approach to treating depression...Impressive and valuable... aimed at the general public, [The Inflamed Mind is] highly readable, and more than a little provocative." -- Kirkus Reviews "[A] targeted, readable primer... [and] a well-informed and cogently argued brief for funding and more investigation in the field." -- Publishers Weekly "Ed Bullmore provides a clearly written and compelling argument for the importance of the immune system and inflammation in depression. This lively book explains a major frontier in clinical neuroscience that is not only influencing research on depression, but also on schizophrenia and Alzheimer's disease." --Steven E. Hyman, Harvard University "An important book, a hopeful book, for anyone whowants to think about depression in a new way." --Tom Insel, MD, cofounder and president of Mindstrong Health " The Inflamed Mind confronts the reader with theconverging revolutions in neuroscience and immunology that give rise to a newperspective about depression and its treatment. It traces the roots of dualism,the tendency to view mind dissociated from body, and then calls for movingbeyond dualism in order to understand how inflammation in the body affectsbrain and mind. In an erudite, enjoyable, and accessible way, Professor Bullmore conveys the profound impact of this new perspective by helping us toappreciate the links between traditional 'medical' and 'psychiatric' syndromesand it identifies new anti-inflammatory treatments that may cross the boundaryfrom general medicine to psychiatry." --John H. Krystal, M.D., Robert L. McNeil, Jr., professor of translational research; chair, department of psychiatry, Yale University School of Medicine "As one of the first people to brand themselves as animmunopsychiatrist, Professor Bullmore has led us out of the dark ages andshone the light on the crucial link between systemic inflammation and mentalillness. This set of insights is creating a paradigm shift in psychiatry whichheralds a new field of personalized psychiatry in the same way that we are seeingpersonalized therapy in chancer." --Sir Robert Lechler, president of the Medical Sciences "Suddenly an expert who wants to stop and questioneverything we thought we knew...This is a lesson in the workings of the brain far too important to ignore." --Jeremy Vine, BBC, "Bullmore takes us through the exciting journey of immuno-psychiatry. He serves as an excellent guide... A tour de force not only because the book makes available to the layman what we have learned on the interactions between the immune system and the brain during the past two decades, but also because it puts it in perspective of the radical divide that unfortunately still separates psychiatry from other branches of medicine." -- Robert Dantzer, BRAIN: A Journal of Neurology "A rousing, straight-from-the shoulder call for a new approach to treating depression...Impressive and valuable... aimed at the general public, [ The Inflamed Mind is] highly readable, and more than a little provocative." -- Kirkus Reviews "[A] targeted, readable primer... [and] a well-informed and cogently argued brief for funding and more investigation in the field." -- Publishers Weekly " The Inflamed Mind is not only a dramatic breakthrough in our understanding of depression. It is an extraordinary exploration of what it is to be human." -- Matthew d'Ancona, author of Post Truth " The Inflamed Mind confronts the reader with the converging revolutions in neuroscience and immunology that give rise to a new perspective about depression and its treatment. It traces the roots of dualism,the tendency to view mind dissociated from body, and then calls for moving beyond dualism in order to understand how inflammation in the body affects brain and mind. In an erudite, enjoyable, and accessible way, Professor Bullmore conveys the profound impact of this new perspective by helping us to appreciate the links between traditional 'medical' and 'psychiatric' syndromes and it identifies new anti-inflammatory treatments that may cross the boundary from general medicine to psychiatry." --John H. Krystal, M.D., Robert L. McNeil, Jr., professor of translational research; chair, department of psychiatry, Yale University School of Medicine "Ed Bullmore provides a clearly written and compelling argument for the importance of the immune system and inflammation in depression. This lively book explains a major frontier in clinical neuroscience that is not only influencing research on depression, but also on schizophrenia and Alzheimer's disease." --Steven E. Hyman, Harvard University "Here is a narrative that tells of exciting new approaches to reducing mental illness while capturing the essence of a powerful strand in fundamental brain science. Even better: it is easy to read without overly simplifying its subject." -- Sir Philip Campbell, Editor-in-Chief, Nature "An important book, a hopeful book, for anyone who wants to think about depression in a new way." --Tom Insel, MD, cofounder and president of Mindstrong Health "As one of the first people to brand themselves as animmunopsychiatrist, Professor Bullmore has led us out of the dark ages and shone the light on the crucial link between systemic inflammation and mental illness. This set of insights is creating a paradigm shift in psychiatry which heralds a new field of personalized psychiatry in the same way that we are seeing personalized therapy in chancer." --Sir Robert Lechler, president of the Academy of Medical Sciences "A compelling and highly readable argument that some forms of mental illness are really diseases of the immune system. If Bullmore is right, psychiatry is on the brink of a revolution--the reunion of body and mind." -- Sir Colin Blakemore, Professor of Neuroscience & Philosophy, School of Advanced Study, University of London "Suddenly an expert who wants to stop and question everything we thought we knew...This is a lesson in the workings of the brain far too important to ignore." --Jeremy Vine, BBC, "Ed Bullmore provides a clearly written and compelling argument for the importance of the immune system and inflammation in depression. This lively book explains a major frontier in clinical neuroscience that is not only influencing research on depression, but also on schizophrenia and Alzheimer's disease." --Steven E. Hyman, Harvard University "An important book, a hopeful book, for anyone whowants to think about depression in a new way." --Tom Insel, MD, cofounder and president of Mindstrong Health " The Inflamed Mind confronts the reader with theconverging revolutions in neuroscience and immunology that give rise to a newperspective about depression and its treatment. It traces the roots of dualism,the tendency to view mind dissociated from body, and then calls for movingbeyond dualism in order to understand how inflammation in the body affectsbrain and mind. In an erudite, enjoyable, and accessible way, Professor Bullmore conveys the profound impact of this new perspective by helping us toappreciate the links between traditional 'medical' and 'psychiatric' syndromesand it identifies new anti-inflammatory treatments that may cross the boundaryfrom general medicine to psychiatry." --John H. Krystal, M.D., Robert L. McNeil, Jr., professor of translational research; chair, department of psychiatry, Yale University School of Medicine "As one of the first people to brand themselves as animmunopsychiatrist, Professor Bullmore has led us out of the dark ages andshone the light on the crucial link between systemic inflammation and mentalillness. This set of insights is creating a paradigm shift in psychiatry whichheralds a new field of personalized psychiatry in the same way that we are seeingpersonalized therapy in chancer." --Sir Robert Lechler, president of the Medical Sciences "Suddenly an expert who wants to stop and questioneverything we thought we knew...This is a lesson in the workings of the brain far too important to ignore." --Jeremy Vine, BBC, "Ed Bullmore provides a clearly written and compelling argument for the importance of the immune system and inflammation in depression. This lively book explains a major frontier in clinical neuroscience that is not only influencing research on depression, but also on schizophrenia and Alzheimer's disease." --Steven E. Hyman, Harvard University "An important book, a hopeful book, for anyone whowants to think about depression in a new way." --Tom Insel, MD, cofounder and president of Mindstrong Health " The Inflamed Mind confronts the reader with theconverging revolutions in neuroscience and immunology that give rise to a newperspective about depression and its treatment. It traces the roots of dualism,the tendency to view mind dissociated from body, and then calls for movingbeyond dualism in order to understand how inflammation in the body affectsbrain and mind. In an erudite, enjoyable, and accessible way, Professor Bullmore conveys the profound impact of this new perspective by helping us toappreciate the links between traditional 'medical' and 'psychiatric' syndromesand it identifies new anti-inflammatory treatments that may cross the boundaryfrom general medicine to psychiatry." --John H. Krystal, M.D., Robert L. McNeil, Jr., professor of translational research; chair, department of psychiatry, Yale University School of Medicine "As one of the first people to brand themselves as animmunopsychiatrist, Professor Bullmore has led us out of the dark ages andshone the light on the crucial link between systemic inflammation and mentalillness. This set of insights is creating a paradigm shift in psychiatry whichheralds a new field of personalized psychiatry in the same way that we are seeingpersonalized therapy in chancer." --Sir Robert Lechler, president of the Medical Sciences "Suddenly an expert who wants to stop and questioneverything we thought we knew...This is a lesson in the workings of the brain fartoo important to ignore." --Jeremy Vine, BBC

TitleLeadingThe

Dewey Decimal616.8527

Table Of ContentCONTENTS List of Figures ix Preface xi One: Daring to think differently 1 Root canal blues Neuro-immunology and immuno-psychiatry What does an inflamed mind look like? The revolution will not be televised Two: The workings of the immune system 20 Inflammation and infection Fig 1. Immune cells Fig 2. Inflammation Location, location, location Communication: the medium is the message Fig 3. The immune system Rapid rebuttal and learning Auto-immunity: the flip side Three: Hiding in plain sight 43 It's depressing being ill The cogito, God, and the machine Fig 4. A lady trying to explain the pineal theory of the human mind and body A long shadow Mrs P is not alone A bona fide blockbuster The Cartesian blind spot Four: Melancholia after Descartes 69 From black bile to MDD A cross to bear Super-shrink Fig 5. Freud's first draft of the ego Dancing in the sanatorium Fig 6. First prophet of pharmaceuticals The golden age Fig 7. Scenes of joy at the dawn of anti-depressants Fig 8. The seer and the synapse Farcical serotonin Bereft of biomarkers Five: How? 112 Extraordinary claims demand extraordinary evidence A stubborn fact Causes must come first The Berlin wall in the brain Fig 9. What I was taught at medical school - and what we now know Fig 10. Nervous reflex control of inflammation Inflamed brains Six: Why? 146 What could make you inflamed (and depressed)? Flaming stressed Causal chains and cycles Ultimately, the answer must always be Darwin Fig 11. Emotional faces and emotional brains A savannah survival story Seven: So what? 176 Medical apartheid Fig 12. The vicious cycle of stress, inflammation and depression - and ways to break it - an artist's impression Could it be different already? Market failure Beyond blockbusters: better but not bigger than Prozac Alzheimer's disease and the yin and yang of microglia Schizophrenia and auto-intoxication References 221 Acknowledgements 229 Disclaimers 230 Index 231

SynopsisAs seen on "CBS This Morning" Worldwide, depression will be the single biggest cause of disability in the next twenty years. But treatment for it has not changed much in the last three decades. In the world of psychiatry, time has apparently stood still...until now with Edward Bullmore's The Inflamed Mind: A Radical New Approach to Depression . A Sunday Times (London) Top Ten Bestseller In this game-changing book, University of Cambridge professor of psychiatry Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation of the body and brain. He explains how and why we now know that mental disorders can have their root cause in the immune system, and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycles of stress, inflammation, and depression. The Inflamed Mind goes far beyond the clinic and the lab, representing a whole new way of looking at how mind, brain, and body all work together in a sometimes misguided effort to help us survive in a hostile world. It offers insights into how we could start getting to grips with depression and other mental disorders much more effectively in the future., As seen on "CBS This Morning" Worldwide, depression will be the single biggest cause of disability in the next twenty years. But treatment for it has not changed much in the last three decades. In the world of psychiatry, time has apparently stood still...until now with Edward Bullmore's The Inflamed Mind: A Radical New Approach to Depression . A Sunday Times (London) Top Ten Bestseller In this game-changing book, University of Cambridge profressor of psychiatry Edward Bullmore reveals the breakthrough new science on the link between depression and inflammation of the body and brain. He explains how and why we now know that mental disorders can have their root cause in the immune system, and outlines a future revolution in which treatments could be specifically targeted to break the vicious cycles of stress, inflammation, and depression. The Inflamed Mind goes far beyond the clinic and the lab, representing a whole new way of looking at how mind, brain, and body all work together in a sometimes misguided effort to help us survive in a hostile world. It offers insights into how we could start getting to grips with depression and other mental disorders much more effectively in the future.

LC Classification NumberRC537.B838 2019