Unusually for me these days i read this one afternoon.
The X chromosone has several serious afflictions allied to it
My brother had serious colourblindness but nothing else. My childhood was marred by aching legs which i believe was a female trait for the more serious male muscular dystrophy. my doctor called it growing pains.
my grandson has Duchesse Muscular dystropy
i went back in family tree to past 1815 and found no others author mentions none of these afflctions. great book though.