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Modern Methods of Drug Discovery by Rolf Hilgenfeld, Alexander Hillisch (Hardcover, 2002)

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There have been dramatic changes in approaches for identifying new chemical entities with a desired biological activity.

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This volume offers a broad and interdisciplinary view of modern approaches to drug discovery as used by pharmaceutical companies and research institutes. It covers proteomics, bioinformatics, screening techniques such as high-throughput-, natural compounds- and NMR-based screenings, combinatorial chemistry, compound library design, ligand- and structure-based drug design and pharmacokinetic approaches. Each of the 13 chapters reviews the theory, background and application of a key technology in drug discovery and is complemented by an extensive list of references to the original literature. This concise source of information should be useful to workers in the pharmaceutical industry, as well as researchers and students in the fields of medicinal, pharmaceutical and computational chemistry, bioinformatics, biochemistry, molecular biology and pharmacology.