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About this product
Product Identifiers
PublisherSpringer
ISBN-100306440555
ISBN-139780306440557
eBay Product ID (ePID)96056
Product Key Features
Number of PagesXi, 461 Pages
Publication NameProstaglandins, Leukotrienes, Lipoxins, and Paf : Mechanisms of Action, Molecular Biology, and Clinical Applications
LanguageEnglish
SubjectLife Sciences / Biochemistry, Endocrinology & Metabolism, Pharmacology
Publication Year1992
TypeTextbook
Subject AreaScience, Medical
AuthorJ. Martyn Bailey
SeriesGwumc Department of Biochemistry and Molecular Biology Annual Spring Symposia Ser.
FormatHardcover
Dimensions
Item Weight87.1 Oz
Item Length10 in
Item Width7 in
Additional Product Features
Intended AudienceScholarly & Professional
LCCN91-032165
Number of Volumes1 vol.
IllustratedYes
SynopsisProceedings of the XIth International Washington Spring Symposium at the George Washington University, held in Washington, D.C., May 13-17, 1991, The field of eicosanoid metabolism and function continues to grow. Synthesis of the prostaglandins from essential fatty acids was first described by Bergstrom and Sarnuelsson in 1964. The thromboxanes were discovered in 1975, the prostacyclins, by Moncada and Vane, in 1976, and the leukotrienes by Samuelsson in 1979. A new class of biologically active arachidonic acid metabolites named lipoxins was announced by Bengt Samuelsson in May 1984. Since that time major advances have been made in the molecular biology of the eicosanoids including the cloning of prostaglandin synthases and 5, 12, and 15-lipoxygenases from several different species, including man. This volume, Prostaglandins, Leukotrienes, Lipoxins, and P AF: Their Mechanism of Action, Molecular Biology, and Clinical Applications contains most of the papers presented in the plenary sessions of the Xlth International Washington Spring Symposium on Health Sciences. The book is divided into six parts, each covering a different aspect of this rapidly expanding field, and contains a total of 42 chapters by an internationally recognized group of authors in each area. Part I contains 11 chapters and covers the molecular biology and enzymology of prostaglandins and leukotrienes. Chapter 1 by the Editor details new mechanisms for the antiinflammatory glucocorticoids involving translational control of the messenger RNA for prostaglandin synthase. Chapter 2 by Yamamoto describes the molecular evolution of two distinct mammalian 12-lipoxygenases.
LC Classification NumberRM300-666
